ATXN8OS (ATXN8 Opposite Strand LncRNA)

Patients in moderate stages were primarily associated with the EMX2OS score. The research findings demonstrate that the nine-lncRNA signature, when combined with deep learning, offers a powerful approach for recurrence risk stratification in cervical cancer.

Network analysis uncovered two divergent interactomes - a focused upregulated network (4 hubs/32 proteins/151 edges) versus an extensive downregulated network (5 hubs/245 proteins/2,826 edges) - suggesting the latter's predominant role in PD progression. Our findings systematically decode ncRNA regulatory architecture in PD, delivering both mechanistic insights and clinically actionable targets for early diagnosis and therapeutic development.

Rescue experiments indicated that ATXN8OS modulated TMZ-resistance of glioma through GLS2. In conclusion, ATXN8OS mediated ferroptosis and regulated the TMZ-resistance of glioma via ADAR/GLS2 pathway.