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    GENE:

    ATRIP (ATR Interacting Protein)

    i
    Other names: ATRIP, ATR Interacting Protein, ATM And Rad3-Related-Interacting Protein, ATR-Interacting Protein, FLJ12343, MGC20625, MGC21482, MGC26740, AGS1
    Associations

    News

    Trials
    2ms
    A Novel ATRIP Mutation Detected in an Iranian Family with Familial Clustering of Breast Cancer: A Case Report. (PubMed, Curr Oncol)
    Further studies are required to confirm the role of ATRIP in breast cancer susceptibility, refine risk assessment, and evaluate potential personalized therapeutic strategies. In the interim, genetic counseling for ATRIP mutation carriers should proceed with caution, given current limitations in clinical interpretation.
    Journal
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    HRD (Homologous Recombination Deficiency) • ATR (Ataxia telangiectasia and Rad3-related protein) • ATRIP (ATR Interacting Protein)
    almost3years
    Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank. (PubMed, Am J Hum Genet)
    Proper activation of ATR-ATRIP elicits a DNA damage checkpoint crucial in regulating cellular responses to DNA replication stress. Based on our observations, we conclude ATRIP is a breast cancer susceptibility gene candidate linking DNA replication stress to breast cancer.
    Journal
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    HRD (Homologous Recombination Deficiency) • ATRIP (ATR Interacting Protein)
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    HRD