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    BIOMARKER:

    ATP5IF1 overexpression

    i
    Other names: ATP5IF1, ATP Synthase Inhibitory Factor Subunit 1, ATPI 2, ATPase Inhibitor, Mitochondrial, ATP Synthase F1 Subunit Epsilon, ATP Synthase Inhibitor Protein, Inhibitor Of F(1)F(O)-ATPase, ATPase Inhibitory Factor 1, ATPase Inhibitor Protein, ATPIF1, ATPIP, IF(1), IF1, IP, ATP5IF1, MGC1167, MGC8898
    Entrez ID:
    93974
    over1year
    scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity. (PubMed, Oncoimmunology)
    Therefore, ATPIF1 is a potential molecular target in the modulation of antitumor immunity of CD8 T cells in cancer immunotherapy. Induction of ATPIF1 activity may promote CAR-T activity in cancer therapy.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • GZMB (Granzyme B) • ATP5IF1 (ATP Synthase Inhibitory Factor Subunit 1)
    |
    IFNG expression • ATP5IF1 overexpression