A significant correlation was observed between the senescence-related lncRNA prognostic model and the tumor microenvironment, immune cell infiltration, and drug sensitivity (p < 0.05). The senescence-related lncRNA prognostic model developed in this work can accurately forecast the prognosis of colon cancer patients, offering new insights for personalized treatment approaches in colon cancer.
At the same time, we found significant differences in the responses to chemoradiotherapy between the two groups, proving the value of mC-LPS in treatment decision-making in ESCC. This study established a novel prognostic signature based on 9 mC-related lncRNAs, which is a promising biomarker for predicting clinical outcomes and therapeutic response in ESCC.