^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    atorvastatin

    i
    Other names: YM 548, CI 981
    Company:
    Generic mfg.
    Drug class:
    HMG-CoA reductase inhibitor
    Related drugs:
    1d
    CDK4/6 inhibitor-statin interaction and rhabdomyolysis in breast cancer treatment: a case-based systematic review. (PubMed, Cancer Chemother Pharmacol)
    Rhabdomyolysis due to CDK4/6 inhibitor-statin interactions is a rare but potentially life-threatening complication. Vigilant monitoring, timely intervention, and tailored treatment strategies are essential for preventing complications and improving patient outcomes.
    Review • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HR positive • HER-2 negative • HR positive + HER-2 negative
    |
    Ibrance (palbociclib) • Verzenio (abemaciclib) • Kisqali (ribociclib) • simvastatin • atorvastatin
    3d
    Study on the Mechanism by Which Atorvastatin Enhances the Stability of Atherosclerotic Plaques in ApoE－/－ Mice Through Regulation of MMP-7/Gα13 (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban)
    Atorvastatin exerts its anti-atherosclerotic effects by regulating blood lipids, inhibiting inflammatory responses, reducing oxidative stress, and regulating apoptosis. It also affects the expression of MMP-7 and Gα13.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • CD68 (CD68 Molecule) • SIRT3 (Sirtuin 3) • APOE (Apolipoprotein E) • NLRP3 (NLR Family Pyrin Domain Containing 3) • MMP7 (Matrix metallopeptidase 7) • SOD2 (Superoxide Dismutase 2)
    |
    atorvastatin
    6d
    Atorvastatin pre-exposure in hypercholesterolemia remedies 27HC mediated dendritic cell dysfunctions in triple-negative breast cancer. (PubMed, Mol Ther Oncol)
    Atorvastatin pre-treatment exerts its action by reducing the availability of intratumoral 27HC and expression of ERα on DCs, which eventually enhances DC functionality and restores their efficiency to prime anti-tumor CD8+ T cell responses. Therefore, atorvastatin pre-exposure adjunct to 27HC-ERα inhibition may serve as an effective immunotherapeutic intervention in TNBC.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CYP27A1 (Cytochrome P450 Family 27 Subfamily A Member 1)
    |
    atorvastatin
    8d
    A Study to Investigate the Effect of Elecoglipron on Rosuvastatin and Atorvastatin in Healthy Participants (clinicaltrials.gov)
    P1, N=48, Active, not recruiting, AstraZeneca | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    atorvastatin
    8d
    DSE-BMP-0005-CIS-MA: Bempedoic acid/ezetimibe/high-intensity statin in patients without cardiovascular events (2025-524625-41-00)
    P2/3, N=69, Not yet recruiting, Daiichi Sankyo Europe GmbH
    New P2/3 trial
    |
    atorvastatin
    9d
    Atorvastatin Combined With NAC Plus Romiplostim for Management of ITP (clinicaltrials.gov)
    P=N/A, N=50, Not yet recruiting, Peking University People's Hospital
    New trial
    |
    atorvastatin • Nplate (romiplostim)
    10d
    RADICAL-PC: A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (clinicaltrials.gov)
    P=N/A, N=5000, Active, not recruiting, McMaster University | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    simvastatin • atorvastatin
    10d
    A Rare Instance of Concordant Charcot-Marie-Tooth Disease and Familial Partial Lipodystrophy Type 2. (PubMed, Cureus)
    Management included custom orthopedic footwear with supramalleolar orthotic (SMO) inserts, endurance-focused physical therapy, gabapentin for neuropathic pain, metformin for dysglycemia, atorvastatin for lipid and atherosclerotic cardiovascular disease (ASCVD) risk reduction, antihypertensive therapy for blood-pressure control, and longitudinal cardiac surveillance with electrocardiogram (ECG), echocardiography, and ambulatory rhythm monitoring. This case highlights the multisystem nature of LMNA-related disease and the importance of recognizing overlapping adipose, neurologic, metabolic, and cardiac manifestations as part of a unified disease process requiring coordinated neuromuscular, endocrine, and cardiology follow-up.
    Journal
    |
    LMNA (Lamin A/C)
    |
    metformin • atorvastatin
    14d
    Atorvastatin Enhances Doxorubicin Efficacy in Breast Cancer Through Convergent Disruption of Drug Efflux, Heat-Shock Response, and DNA Hypermethylation. (PubMed, Curr Pharm Des)
    Given its established clinical safety, atorvastatin represents a practical candidate for repurposing to improve anthracycline-based breast cancer therapy.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • ANXA5 (Annexin A5) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1)
    |
    doxorubicin hydrochloride • atorvastatin
    16d
    Statins Study in Children of Acute Kawasaki Disease With Coronary Artery Abnormalities (clinicaltrials.gov)
    P3, N=9, Recruiting, Children's Hospital of Fudan University | Not yet recruiting --> Recruiting | Phase classification: P --> P3
    Enrollment open • Phase classification
    |
    atorvastatin
    16d
    A Study to Assess the Effect of HRS-1301 on the Pharmacokinetics of Midazolam and Atorvastatin in Healthy Participants (clinicaltrials.gov)
    P1, N=16, Recruiting, Shandong Suncadia Medicine Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    atorvastatin
    17d
    A Clinical Study of Ulonivirine (MK-8507) With Atorvastatin and Metformin in Healthy Adults (MK-8507-018) (clinicaltrials.gov)
    P1, N=12, Completed, Merck Sharp & Dohme LLC | Active, not recruiting --> Completed
    Trial completion
    |
    atorvastatin