^
    over3years
    Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells. (PubMed, Mol Biol Rep)
    Atiprimod induced prolonged ER stress-mediated apoptosis via both activating PERK/eIF2α/ATF4/CHOP axis and suppressing STAT3/NF-κB transcription factors nuclear migration in TBNC cells.
    Journal
    |
    STAT3 (Signal Transducer And Activator Of Transcription 3) • STAT1 (Signal Transducer And Activator Of Transcription 1) • ATF4 (Activating Transcription Factor 4) • BECN1 (Beclin 1) • RELA (RELA Proto-Oncogene)
    |
    STAT3 expression • PERK expression
    |
    atiprimod (SK&F106615)