our Premium Content: News alerts, weekly reports and conference planners

GENE:

ATG2B (Autophagy Related 2B)

News alerts, weekly reports and conference planners

4ms

Germline predisposition to acute myeloid leukemia in polish patients. (PubMed, Leuk Lymphoma)

The median age at AML diagnosis was six years younger in patients carrying germline variants compared to those without. The identification of AML susceptibility genes enhances our understanding of the disease pathogenesis, aids help with recognizing in recognizing individuals at elevated risk, forms the basis for genetic counseling and patient management, assists in selecting suitable donors for allogeneic hematopoietic stem cell transplantation, and supports the development of targeted therapeutic strategies.

4 months ago

Journal

KMT2A (Lysine Methyltransferase 2A) • ANKRD26 (Ankyrin Repeat Domain Containing 26) • ATG2B (Autophagy Related 2B)

5ms

The methylation-expression correlation of autophagy-related genes in colorectal cancer patients from southern Iran. (PubMed, Mol Biol Res Commun)

This highlights the complexity of the epigenetic regulation of ATG2B, ATG4D, ATG9A and ATG9B genes in CRC. Further large-scale studies will contribute to discovering the exact influences of ATG methylation in CRC carcinogenesis and thereby may thereby provide novel targets and biomarkers for this lethal illness.

5 months ago

Journal

ATG2B (Autophagy Related 2B) • ATG9B (Autophagy Related 9B)

8ms

Exploring the interplay between EBV and autophagy-related gene expression patterns in nasopharyngeal carcinoma. (PubMed, Front Oncol)

Reduced ATG4D mRNA levels were also correlated with higher metastasis rates and shorter distant metastasis-free survival (DMFS), highlighting a potential association of ATG4D with DMFS. Overall, these findings emphasize the importance of assessing autophagy-related gene expression as a valuable tool for predicting clinical outcomes in NPC and underscore the need for further research to validate these results and explore therapeutic implications.

8 months ago

Journal

ATG5 (Autophagy Related 5) • ATG2B (Autophagy Related 2B) • ATG3 (Autophagy Related 3) • ATG4B (Autophagy Related 4B Cysteine Peptidase) • ATG4C (Autophagy Related 4C Cysteine Peptidase)

9ms

Impact of carboxymethyl dextran-asparaginase in NALM-6 cell apoptosis and autophagy. (PubMed, Iran J Vet Res)

Interestingly, the modified enzyme had a lesser effect on autophagy, which is important as excessive autophagy can lead to treatment resistance. These findings suggest that the modified L-ASNase may have the potential to be a more effective chemotherapeutic agent for ALL treatments.

9 months ago

Journal

ANXA5 (Annexin A5) • ATG2B (Autophagy Related 2B)

12ms

ATG2A acts as a tether to regulate autophagosome-lysosome fusion in neural cells. (PubMed, Autophagy)

ATG2 and another tether protein, EPG5, function partially redundantly in mediating autophagosome-lysosome fusion. Thus, ATG2A plays a key role in neural autophagy by tethering autophagosomes with lysosomes for fusion.

12 months ago

Journal

SQSTM1 (Sequestosome 1) • ATG2B (Autophagy Related 2B)

over1year

Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer. (PubMed, Metabolism)

Pae can serve as an effective, low-toxicity, multi-targeted drug targeting ACSS2 and glycolysis. It activates autophagy through the ACSS2/SIRT1/ATG5/ATG2B deacetylation signalling cascade, thereby exerting anti-OC effects. Our study provides new insights into the malignant mechanisms of OC and offers a novel strategy for its treatment.

over 1 year ago

Journal

ATG5 (Autophagy Related 5) • SIRT1 (Sirtuin 1) • ACSS2 (Acyl-CoA Synthetase Short Chain Family Member 2) • ATG2B (Autophagy Related 2B)

over1year

Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8. (PubMed, Cell Death Dis)

Concurrently, ATG2B, an acetylated protein, is subjected to SIRT1-mediated deacetylation, enhancing its binding to RNF5. Consequently, we established a novel mechanism for the role of circDHX8 in the malignant progression of GC.

over 1 year ago

Journal

SIRT1 (Sirtuin 1) • ATG2B (Autophagy Related 2B) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5)

almost2years

Knockdown mitochondrial transcription factor A (TFAM) inhibits autophagy, proliferation, invasion and migration in human cervical cancer and osteosarcoma cells (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)

The proliferation, invasion and migration ability of HeLa and U2OS cells were inhibited after being interfered with TFAM expression. Conclusion Downregulation of TFAM expression inhibits mitochondrial function, delays autophagy process and reduces the proliferation, invasion and migration ability of cervical cancer cells and osteosarcoma cells.

almost 2 years ago

Journal

MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) • SNAI1 (Snail Family Transcriptional Repressor 1) • ATG2B (Autophagy Related 2B) • MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha) • TFAM (Transcription Factor A, Mitochondrial)

almost2years

Additional prognostic value of polymorphisms within the 3'-untranslated region of programmed cell death pathway genes in early-stage breast cancer. (PubMed, Front Immunol)

Receiver operating characteristic curve analysis demonstrated that incorporating unfavorable genotypes and clinicopathological variables improved the ability to predict EBC survival (P = 0.006, 0.004, 0.029, and 0.019 for iDFS, DDFS, BCSS, and OS, respectively). Additionally, rs6753785 and rs2213181 were associated with BCL2L11 and c-Kit mRNA expression, respectively. Our results suggest that these four SNPs may act as novel biomarkers for EBC survival, possibly by modulating the expression of the corresponding genes.

almost 2 years ago

Journal

KIT (KIT proto-oncogene, receptor tyrosine kinase) • BCL2L11 (BCL2 Like 11) • ATG2B (Autophagy Related 2B)

KIT expression

almost2years

Predictive Role of Cluster Bean (Cyamopsis tetragonoloba) Derived miRNAs in Human and Cattle Health. (PubMed, Genes (Basel))

We also found a few cb-miRs that do not have functional similarity with human and cattle miRNAs but are found to target the genes in the host organisms and as well being associated with human and cattle diseases. Interestingly, a few genes such as NRM, PTPRE and SUZ12 were observed to be associated with Rheumatoid Arthritis, Asthma and Endometrial Stromal Sarcoma diseases, respectively, in humans and genes like SCNN1B associated with renal disease in cattle.

almost 2 years ago

Journal

ATG2B (Autophagy Related 2B) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit)

over2years

Clinical and Molecular Characterization of Triple-Negative Essential Thrombocythemia: Data from the Prospective Spanish Registry of Essential Thrombocythemia (ASH 2023)

The detection of P/PP mutations in patients diagnosed with TN-ET is associated with a higher risk of transformation to AL and lower overall survival, but not with higher risk of thrombosis or progression to MF. It is necessary to evaluate the individual risk of each of these mutations and the potential prognostic role of variants of US.

over 2 years ago

Clinical

KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • FLT3 (Fms-related tyrosine kinase 3) • NRAS (Neuroblastoma RAS viral oncogene homolog) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • NF1 (Neurofibromin 1) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • KMT2A (Lysine Methyltransferase 2A) • TET2 (Tet Methylcytosine Dioxygenase 2) • ETV6 (ETS Variant Transcription Factor 6) • PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) • SRSF2 (Serine and arginine rich splicing factor 2) • WT1 (WT1 Transcription Factor) • BCOR (BCL6 Corepressor) • CSF3R (Colony Stimulating Factor 3 Receptor) • KDM6A (Lysine Demethylase 6A) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • STAG2 (Stromal Antigen 2) • EPAS1 (Endothelial PAS domain protein 1) • SETBP1 (SET Binding Protein 1) • MBD4 (Methyl-CpG Binding Domain 4, DNA Glycosylase) • CUX1 (cut like homeobox 1) • DDX41 (DEAD-Box Helicase 41) • GNAS (GNAS Complex Locus) • GATA2 (GATA Binding Protein 2) • PHF6 (PHD Finger Protein 6) • PPM1D (Protein Phosphatase Mg2+/Mn2+ Dependent 1D) • RAD21 (RAD21 Cohesin Complex Component) • CALR (Calreticulin) • SH2B3 (SH2B Adaptor Protein 3) • ETNK1 (Ethanolamine Kinase 1) • RIT1 (Ras Like Without CAAX 1) • ZRSR2 (Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2) • ANKRD26 (Ankyrin Repeat Domain Containing 26) • ATG2B (Autophagy Related 2B) • BCORL1 (BCL6 Corepressor Like 1) • EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1) • SMC1A (Structural Maintenance Of Chromosomes 1A) • PRPF8 (Pre-MRNA Processing Factor 8)

U2AF1 mutation • JAK2 V617F

almost3years

Identification of an Autophagy-Related Signature for Prognosis and Immunotherapy Response Prediction in Ovarian Cancer. (PubMed, Biomolecules)

The autophagy-related signature is applicable to predict the prognosis and immune checkpoint inhibitors (ICIs) therapy efficiency in OC patients. It is possible to identify OC patients who will respond to ICIs therapy and have a favorable prognosis, although more verification is needed.

almost 3 years ago

Journal • IO biomarker

DAPK1 (Death Associated Protein Kinase 1) • AMBRA1 (Autophagy And Beclin 1 Regulator 1) • ATG2B (Autophagy Related 2B) • LAMP2 (Lysosomal Associated Membrane Protein 2) • PDPK1 (3-Phosphoinositide dependent protein kinase 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) • TRAF6 (TNF Receptor Associated Factor 6)