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    BIOMARKER:

    ATF6 overexpression

    i
    Other names: ATF6, Activating Transcription Factor 6, Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha, CAMP-Dependent Transcription Factor ATF-6 Alpha, Activating Transcription Factor 6 Alpha, ATF6A, ATF6-Alpha, ACHM7
    Entrez ID:
    22926
    23d
    Identification of activating transcription factor 6 (ATF6) as a novel prognostic biomarker and potential target in oral squamous cell carcinoma. (PubMed, Gene)
    We propose that ATF6 holds potential as a prognostic biomarker linked to autophagy in OSCC. This study provides valuable clues for further exploration of targeted therapy against OSCC.
    Journal
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    ATF6 (Activating Transcription Factor 6)
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    ATF6 overexpression
    1year
    EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (AACR 2023)
    These data suggest EZH2 and ATF6 act to balance MHC-I antigen presentation during metabolic stress whereby loss of EZH2 increases and activation of ATF6 prevents MHC antigen presentation. Additional and ongoing studies coupling EZH2 and ATF6 inhibition will provide crucial insight into this mechanism and have the potential to influence adjuvant therapy development.
    Late-breaking abstract • IO biomarker
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    JAK1 (Janus Kinase 1) • ATF6 (Activating Transcription Factor 6) • IFNAR1 (Interferon (alpha, beta and omega) receptor 1)
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    ATF6 overexpression
    2years
    miR-340-5p affects oral squamous cell carcinoma (OSCC) cells proliferation and invasion by targeting endoplasmic reticulum stress proteins. (PubMed, Eur J Pharmacol)
    PERK or ATF6 overexpression dramatically attenuated phenotypes of miR-340-5p up-regulation. Altogether, miR-340-5p targets the endoplasmic reticulum stress proteins PERK and ATF6 to affect OSCC cell proliferation and invasion.
    Journal
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    ATF6 (Activating Transcription Factor 6) • MIR340 (MicroRNA 340) • PERK (Pancreatic EIF2-Alpha Kinase) • TFAM (Transcription Factor A, Mitochondrial)
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    ATF6 overexpression • miR-340 expression • PERK expression