aspirin

Adjuvant treatment with VD can increase the proportion of regulatory T cells in peripheral blood of individuals with recurrent abortion, regulate metabolic disorder, alleviate immune inflammation, and improve pregnancy outcome.

Molecular docking studies revealed that selected protein targets strongly interact with bioactive compounds, and the estimated inhibition constants (Ki) of JAK2, STAT3, COX-2, HPV31 E6, EGFR1, TP53, and PARP1 were significantly decreased compared to acetylsalicylic acid. This could be a clear indication that these protein targets are implicated with antiproliferative efficacy, thereby warranting the potential of (1) and (7) to be used as anti-breast cancer drug candidates.

SANT of the spleen is generally considered a rare, benign lesion with angioma-like characteristics. It exhibits exhibiting distinctive histomorphological features within the red pulp. Understanding the differential diagnosis is crucial to prevent missed or incorrect diagnoses.

P3, N=1184, Recruiting, Capital Medical University | Not yet recruiting --> Recruiting

P4, N=1050, Not yet recruiting, Affiliated Hospital of Guangdong Medical University; Affiliated Hospital of Guangdong Medical University

P2, N=150, Completed, Peter MacCallum Cancer Centre, Australia | Unknown status --> Completed

P3, N=21, Completed, PharmaEssentia Japan K.K. | Recruiting --> Completed

P=N/A, N=1200, Active, not recruiting, Washington University School of Medicine | Not yet recruiting --> Active, not recruiting | N=400 --> 1200 | Trial completion date: Jun 2024 --> Nov 2024

Thus, this pilot study suggests that the reduction in p87 in the right colon is possibly correlated with JAK3 mutations. If confirmed, JAK3 mutations, known to be associated with immune aberrations, may provide a mechanistic explanation for the lack of a p87 (protein 87 kilodaltons) field in some patients with HGD polyps who might benefit from possible intervention such as more intensive screening. Limited microbiome studies were also performed on two patients with familial cancer syndromes and these compared favorably with controls available from the literature.

P4, N=10742, Recruiting, Ohio State University | Not yet recruiting --> Recruiting

P4, N=70, Not yet recruiting, PharmaEssentia | N=110 --> 70 | Trial completion date: Feb 2027 --> Jun 2026 | Initiation date: Jul 2024 --> Jan 2025

P3, N=700, Recruiting, Weill Medical College of Cornell University | Not yet recruiting --> Recruiting

P3, N=400, Active, not recruiting, Weill Medical College of Cornell University | Enrolling by invitation --> Active, not recruiting | Trial completion date: Aug 2024 --> Nov 2024 | Trial primary completion date: Aug 2024 --> Nov 2024

P3, N=1184, Not yet recruiting, Capital Medical University | Initiation date: Aug 2024 --> Nov 2024

P4, N=44, Active, not recruiting, Lawson Health Research Institute | Recruiting --> Active, not recruiting | Trial completion date: Apr 2025 --> Jul 2026 | Trial primary completion date: Feb 2025 --> Feb 2026

P1/2, N=32, Not yet recruiting, University of Aarhus

P1, N=38, Not yet recruiting, Bayer

P4, N=128, Recruiting, Columbia University

P3, N=3200, Recruiting, Children's Hospital of Fudan University | Trial completion date: Sep 2025 --> Dec 2025 | Trial primary completion date: Sep 2024 --> Dec 2024

P2/3, N=100, Not yet recruiting, Mazandaran University of Medical Sciences

In this study, we found that all of the hub genes are linked with the 10 drug components, and it was observed that aspirin CTD 00005447 was mostly associated with all the other hub genes. This bio-informatics study may help researchers better understand the cause of PTB and its relationship with NCDs, and eventually, this can lead to exploring effective treatment plans.

PV patients with high risk can benefit from low-dose aspirin...Patients with polycythemia vera can present with a high or low serum EPO level. Further diagnostic tests are usually required to confirm the final diagnosis.

However, low-dose aspirin can diminish the apoptotic signal of reproductive cells in C. elegans and exert anti-inflammatory effects. Our research results suggest that the tumor-suppressive and radio/chemo-therapy sensitizing effects of aspirin provide robust experimental evidence for improving the clinical efficacy of tumor radio/chemo-therapy and deepening our understanding of aspirin's mechanism of action in cancer.

In addition, AKR1C1 is identified as a potential therapeutic target and demonstrated the inhibitory effect of aspirin and dydrogesterone as its inhibitors on tumor cells. The integrative multi-omics analysis helps to understand the progression of BRDC and provides an opportunity to treat BRDC in different stages.

P=N/A, N=230, Recruiting, Yonsei University | Trial completion date: Jul 2025 --> Jul 2027 | Trial primary completion date: Jul 2024 --> Jul 2026

Here, we report that c-Myc can activate both lipid and serine metabolism against the backdrop of tumor formation, and different therapies like aspirin and lomitapide target the links between c-Myc and metabolism to slow down tumor progression and invasion. Finally, we also summarize the existing knowledge on the involvement of epigenetic pathways and non-coding RNAs in regulating lipid and serine metabolism and c-Myc in tumor cells. Identification of non-coding factors and epigenetic mechanisms present a promising avenue of study that could empower researchers with novel anticancer treatment targeting c-Myc and lipid and serine metabolism pathways!

This case highlights the importance of recognizing dynamic changes in routine blood tests that may link CVST to underlying hematological disorders. The JAK2 mutation is not only associated with MPNs but also increases the risk of thrombosis, including CVST. Further investigation is warranted to better understand the mechanisms by which JAK2 mutations contribute to thrombosis and to explore the potential benefits of JAK2 inhibitors in reducing this risk.

P4, N=60, Completed, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

P1, N=161, Active, not recruiting, Massachusetts General Hospital | Recruiting --> Active, not recruiting

P1, N=224, Recruiting, Regeneron Pharmaceuticals | Not yet recruiting --> Recruiting

P4, N=105, Completed, University of Florida | Active, not recruiting --> Completed

P2, N=5478, Recruiting, University of Miami | Trial completion date: Mar 2025 --> Mar 2026 | Trial primary completion date: Mar 2025 --> Mar 2026

Our findings suggest that Aspirin exhibits the potential to reduce Ponatinib-induced cardiovascular toxicity.

Conversely, low-dose aspirin, which is used as a preventive treatment for PE, could inhibit the increase of CD61 and sST2 under inflammatory stimuli and platelet activation in NP but not in PE...Therefore, the findings suggesting a loss of tuning of both pro-coagulant and inflammatory responses on monocytes help in understanding the pathology of PE. The harmonization between pro-coagulant responses, inflammatory responses, and angiogenesis may serve as useful indicators for the prediction and preventive treatment of PE.

P4, N=252, Recruiting, Fu Wai Hospital, Beijing, China | Not yet recruiting --> Recruiting | Trial completion date: Oct 2026 --> Oct 2027 | Trial primary completion date: Oct 2024 --> Oct 2026

P=N/A, N=640, Recruiting, Geisinger Clinic | Trial primary completion date: Jun 2024 --> Apr 2025

P4, N=100, Not yet recruiting, Ochsner Health System

P=N/A, N=60, Active, not recruiting, NHS Lothian | Unknown status --> Active, not recruiting | Trial completion date: Feb 2022 --> Aug 2025 | Trial primary completion date: Feb 2022 --> Aug 2025

Univariate and multivariate Cox regression analysis results showed that aspirin use history, vascular thrombus, neural invasion, CA19-9, N stage, operation time, M stage, and PBCS were independent factors affecting OS (all P<0.05)... This study demonstrates that the PBCS constructed based on preoperative peripheral blood levels of neutrophils, lymphocytes, and platelets is an independent factor associated with the prognosis of patients with colorectal cancer. The nomogram model constructed based on this score system exhibits good predictive efficacy for the prognosis of these patients.

32 (80 %) were treated with low-dose aspirin, and 20 (50 %) underwent at least one phlebotomy...CE is an extremely rare condition. Genetic testing is advised in young individuals with a long-standing persistent erythrocytosis, possibly with a family history and after exclusion of more frequent secondary causes and polycytemia vera.

P3, N=870, Recruiting, Kafrelsheikh University

P3, N=900, Recruiting, Kafrelsheikh University