aspirin

The patient received therapeutic anticoagulation, low-dose aspirin, and hydroxyurea. This case highlights the role of multimodal imaging in diagnosis and risk stratification, and the need to consider masked polycythemia vera in unprovoked pulmonary embolism with unexplained microcytosis and elevated red blood cell count.

P=N/A, N=1172, Not yet recruiting, Shanghai Zhongshan Hospital

P1, N=18, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Jun 2026 --> Jun 2029

Acetylsalicylic acid (ASA) decreased the abundance of metabolic proteins in CALR Type1 platelets, whereas JAK2 V617F platelets showed only minor, heterogeneous increases restricted to a subset of proteins and samples. In functional assays, JAK2 V617F platelets showed aggregation responses similar to or lower than those of healthy controls, whereas untreated CALR Type2 platelets showed higher CD62P expression, indicating a more activated phenotype than the other ET groups. These findings indicate that ET platelets display mutation-associated proteomic and functional differences and suggest that an altered metabolic state may contribute to platelet reactivity.

P=N/A, N=40, Recruiting, Al-Azhar University

P3, N=15160, Not yet recruiting, Hospital Universitari Vall d'Hebron Research Institute

P3, N=768, Recruiting, ANRS, Emerging Infectious Diseases | Trial completion date: Apr 2026 --> Sep 2026 | Trial primary completion date: Sep 2025 --> Sep 2026

These findings suggest that acetylsalicylic acid may influence selected oxidative stress-related parameters in specific brain regions following white noise exposure. However, the observed effects were limited and not consistent across all biochemical and inflammatory markers examined. Further studies are needed to clarify the optimal dose and duration of ASA treatment for controlling stress-related effects.

P2, N=34, Not yet recruiting, University Hospital, Tours

Demographic characteristics were comparable across groups, though comorbidities were more frequent in MPNs. Laboratory analyses confirmed expected disease-specific differences, including elevated leukocyte, neutrophil, and platelet counts in MPNs and prolonged activated partial thromboplastin time in hemophilia A. Circulating citrullinated histone H3 (cit-H3) levels differed significantly among groups (p < 0.001), being lowest in controls, intermediate in MPNs, and highest in hemophilia A. Within disease groups, cit-H3 levels were unaffected by clinical variables such as MPN subtype, aspirin use, phlebotomy history, or factor replacement regimen.ConclusionsElevated circulating cit-H3 levels, suggestive of increased NETosis activity, were observed in both thrombosis-prone MPNs and bleeding-prone hemophilia A. These exploratory findings suggest a possible association between NET formation and thromboinflammatory processes across distinct hemostatic disorders.

P3, N=300, Not yet recruiting, Xuanwu Hospital, Beijing

P1, N=16, Recruiting, Bayer