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DRUG:

ASP0739

i
Other names: ASP0739, artificial adjuvant vector cells, NY-ESO-1 loaded artificial adjuvant vector cell
Associations
Company:
Astellas, Riken
Drug class:
Cell replacement
Associations
4ms
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=16, Terminated, Astellas Pharma Global Development, Inc. | Completed --> Terminated; The comprehensive assessment of other studies indicated the lack of significant monotherapy activity, therefore, team decided to terminate the study.
Trial termination • Combination therapy • Metastases
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
Keytruda (pembrolizumab) • ASP0739
over1year
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=16, Completed, Astellas Pharma Global Development, Inc. | Active, not recruiting --> Completed | N=339 --> 16 | Trial completion date: Jul 2024 --> May 2023 | Trial primary completion date: Jul 2024 --> May 2023
Trial completion • Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739
over1year
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=339, Active, not recruiting, Astellas Pharma Global Development, Inc. | Trial completion date: Jan 2028 --> Jul 2024 | Trial primary completion date: Jan 2026 --> Jul 2024
Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739
almost2years
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=339, Active, not recruiting, Astellas Pharma Global Development, Inc. | Recruiting --> Active, not recruiting
Enrollment closed • Combination therapy • Metastases
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739
almost3years
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=339, Recruiting, Astellas Pharma Global Development, Inc. | Initiation date: Oct 2021 --> Jan 2022
Trial initiation date • Combination therapy
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739
3years
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=339, Recruiting, Astellas Pharma Global Development, Inc. | Not yet recruiting --> Recruiting
Clinical • Enrollment open • Combination therapy
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739
3years
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants (clinicaltrials.gov)
P1/2, N=339, Not yet recruiting, Astellas Pharma Global Development, Inc. | Trial primary completion date: Jul 2024 --> Jan 2026
Clinical • Trial primary completion date • Combination therapy
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739
over3years
Clinical • New P1/2 trial • Combination therapy
|
PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B) • SSX1 (SSX Family Member 1)
|
CTAG1B expression
|
Keytruda (pembrolizumab) • ASP0739