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DRUG:

JNJ-8177

i
Other names: JNJ8177, JNJ 8177, JNJ-8177, ARX517, ARX517-PSMA-ADC, ARX 517, ARX-517
Company:
J&J
Drug class:
Tubulin inhibitor, PSMA-targeted antibody-drug conjugate
7ms
APEX-01: ARX517 in Subjects With Metastatic Castration-Resistant Prostate Cancer (clinicaltrials.gov)
P1, N=262, Recruiting, Ambrx, Inc. | Phase classification: P1/2 --> P1
Phase classification • Metastases
|
FOLH1 (Folate hydrolase 1)
|
FOLH1 expression
|
JNJ-8177
11ms
Trial completion date • Trial primary completion date • Metastases
|
FOLH1 (Folate hydrolase 1)
|
FOLH1 expression
|
Xtandi (enzalutamide capsule) • JNJ-8177
almost1year
Enrollment change • Metastases
|
FOLH1 (Folate hydrolase 1)
|
FOLH1 expression
|
Xtandi (enzalutamide capsule) • JNJ-8177
over1year
ARX517-2011: ARX517 in Subjects With Metastatic Castration-resistant Prostate Cancer (clinicaltrials.gov)
P1/2, N=150, Recruiting, Ambrx, Inc. | Phase classification: P1 --> P1/2 | N=76 --> 150 | Trial completion date: Aug 2024 --> Mar 2027 | Trial primary completion date: Feb 2024 --> Dec 2025
Phase classification • Enrollment change • Trial completion date • Trial primary completion date
|
JNJ-8177
over1year
Preclinical characterization of ARX517, a next-generation anti-PSMA antibody drug conjugate for the treatment of metastatic castration-resistant prostate cancer (AACR 2023)
The serum stability of ARX517 should effectively deliver more payload to target tumor cells, and in multiple CDX and PDX prostate cancer models, ARX517 showed dose-dependent anti-tumor activity in both enzalutamide-sensitive and enzalutamide-resistant models. The strong preclinical data and recent clinical validation of PSMA as a mCRPC target provide rationale for evaluation of ARX517 as a potential prostate cancer treatment. ARX517 is currently in a Phase 1 dose escalation trial (ARX517-2011 [NCT04662580]) in the United States.
Preclinical • Metastases
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FOLH1 (Folate hydrolase 1)
|
FOLH1 expression • FOLH1 overexpression
|
Xtandi (enzalutamide capsule) • JNJ-8177