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    GENE:

    ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11)

    i
    Other names: ARHGEF11, Rho Guanine Nucleotide Exchange Factor 11, PDZ-RHOGEF, KIAA0380, GTRAP48, Rho Guanine Nucleotide Exchange Factor (GEF) 11, Glutamate Transporter EAAT4-Associated Protein 48, RhoA-Specific Guanine Nucleotide Exchange Factor, Rho Guanine Exchange Factor (GEF) 11, RhoGEF Glutamate Transport Modulator, PDZ-RhoGEF
    Associations

    News

    Trials
    10d
    Pediatric NTRK-rearranged gliomas: A clinicopathological and molecular analysis of six cases. (PubMed, Pathol Res Pract)
    This study expands the clinicopathological and molecular spectrum of pediatric NTRK-rearranged gliomas, including rare entities and complex fusion patterns, and supports routine NTRK testing in pediatric gliomas irrespective of histological grade.
    Journal
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    TP53 (Tumor protein P53) • ABL1 (ABL proto-oncogene 1) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • ETV6 (ETS Variant Transcription Factor 6) • MSH2 (MutS Homolog 2) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CHEK1 (Checkpoint kinase 1) • NTRK (Neurotrophic receptor tyrosine kinase) • ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11)
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    NTRK fusion
    over2years
    Oncogenic Gαq activates RhoJ through PDZ-RhoGEF. (PubMed, Int J Mol Sci)
    In conclusion, we demonstrated that an oncogenic Gα mutant enables the PDZ-RhoGEF DH-PH module to recognize RhoJ, suggesting an allosteric mechanism by which this constitutively active GTPase stimulates RhoJ via PDZ-RhoGEF. These findings highlight PDZ-RhoGEF and RhoJ as potential targets in tumors driven by mutant Gαq.
    Journal
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    RHOA (Ras homolog family member A) • CDC42 (Cell Division Cycle 42) • ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11)
    almost4years
    The association of genetic alterations with response rate in newly diagnosed chronic myeloid leukemia patients. (PubMed, Leuk Res)
    Seventy-two patients from 16 institutions were enrolled and treated with a TKI, nilotinib...In conclusion, we found that rapidity of response to TKI was associated with pathway-associated genetic alterations in immune cells, particularly with respect to NK cell activity. These results suggested that the innate immune system at initial diagnosis had an important role in treatment response in patients with CML.
    Journal
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    ABL1 (ABL proto-oncogene 1) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD2 (CD2 Molecule) • ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11) • BLNK (B Cell Linker) • GPR183 (G Protein-Coupled Receptor 183) • PTPRCAP (Protein Tyrosine Phosphatase Receptor Type C Associated Protein) • SHKBP1 (SH3KBP1 Binding Protein 1) • TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2)
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    nilotinib