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BIOMARKER:
ARHGAP20 expression
i
Other names: ARHGAP20, Rho GTPase Activating Protein 20, Rho-Type GTPase-Activating Protein 20, Rho GTPase-Activating Protein 20, Rho GTPase Activating Protein 20 Variant 2, RA And RhoGAP Domain Containing Protein, RARHOGAP, KIAA1391
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Furthermore, we revealed that downregulated ARHGAP20 was significantly correlated with larger tumor size and vascular invasion, and could be used as an adverse independent prognostic factor for HCC OS but not RFS. ARHGAP20 was identified for the first time as a tumor suppressor gene that could inhibit HCC progression by regulating the PI3K-AKT signaling pathway and the immune microenvironment in HCC.