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    GENE:

    AQP1 (Aquaporin 1)

    i
    Other names: AQP1, Aquaporin 1 (Colton Blood Group), CHIP28, Aquaporin 1 (Channel-Forming Integral Protein, 28kDa, CO Blood Group), Water Channel Protein For Red Blood Cells And Kidney Proximal Tubule, Urine Water Channel, Aquaporin-CHIP, Aquaporin-1, Aquaporin 1 (Channel-Forming Integral Protein, 28kDa), Channel-Like Integral Membrane Protein, 28-KDa, Aquaporin 1, Colton Blood Group Antigen, Colton Blood Group, Aquaporin 1, AQP-CHIP, AQP-1, AQP1, CO
    7d
    The relevance of considering metal-ligand speciation in aquaporin modulation by cu, Zn, and V complexes with 1,10-phenanthroline ligands. (PubMed, J Inorg Biochem)
    Speciation modelling indicates that hydrolysis and the formation of multiple metal-containing species occur under experimental conditions, except for Cu(Xphen)22+ complexes. These results highlight the importance of considering metal complex speciation in biological environments and suggest that encapsulation strategies may be required to preserve the integrity of labile metal complexes.
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    AQP1 (Aquaporin 1)
    12d
    Inflammatory Factors Derived From Metabolic Dysfunction-Alcoholic Fatty Liver Disease: Inducers of Anxiety and Spatial Memory Impairment. (PubMed, Mediators Inflamm)
    Taken together, our findings identify MASLD as a modifiable risk factor for neurodegeneration, with systemic inflammation playing a pivotal role in the liver-brain axis. This study highlights key genes and pathways underlying MASLD-induced cognitive impairment, advances understanding of metabolic-neural cross talk, and offers potential therapeutic targets for mitigating cognitive decline through intervention in the liver-brain axis, developing intervention strategies and highlight the therapeutic promise of targeting the liver-brain axis.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TCF7L2 (Transcription Factor 7 Like 2) • AQP1 (Aquaporin 1)
    26d
    Aquaporin-1 differentiates intrahepatic cholangiocarcinoma from liver metastases of pancreatic ductal adenocarcinoma. (PubMed, Histopathology)
    AQP1 is a novel biliary biomarker which has been shown to outperform other biliary biomarkers. The main diagnostic scenario in which AQP1 staining should be used is to distinguish iCCA from mPDAC. Furthermore, differential diagnosis between eCCA and PDAC in surgical specimens and between PDAC and CP in needle biopsies should be considered.
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    AQP1 (Aquaporin 1)
    27d
    Engineering AQP1-Deficient DF-1 Suspension Cells for High-Yield IBDV Production and Vaccine Scale-Up. (PubMed, Vaccines (Basel))
    Virus production time was shortened in suspension cultures. Targeted AQP1 disruption converts DF-1 cells into a stable, non-tumorigenic suspension cell line with markedly enhanced IBDV production, providing a scalable platform for next-generation avian vaccine manufacturing.
    Journal
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    AQP1 (Aquaporin 1)
    1m
    Molecular mechanisms of aquaporin 1 inhibition by Bacopaside I and Bacopaside II: Insights from molecular dynamics simulations. (PubMed, J Mol Graph Model)
    Energy decomposition analysis identifies key interacting residues Pro171, Ile174, and Ala66 that anchor the inhibitors. Although both ligands induce subtle constriction of the channel pores, Bacopaside II establishes a more persistent hydrogen bonding network, underscoring its unique energetic contribution to the inhibition profile. Overall, these findings provide a detailed mechanistic blueprint for AQP1 inhibition by Bacopasides and offer a structural framework for the rational design of next-generation AQP1-targeted anticancer therapies.
    Journal
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    AQP1 (Aquaporin 1)
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    carfilzomib
    1m
    Cross-Regional Transcriptome Data Reveal Transcriptional Abnormalities Associated with Lung Adenocarcinoma. (PubMed, Rep Biochem Mol Biol)
    Our findings suggest that the expression levels of serglycin, ILK, ESD, and PLPD1 may play a significant role in the development of LAC. This information can be valuable for identifying potential treatment targets for lung cancer.
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    CD123 (Interleukin 3 Receptor Subunit Alpha) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • KRT19 (Keratin 19) • AQP1 (Aquaporin 1) • BST1 (Bone Marrow Stromal Cell Antigen 1) • COL3A1 (Collagen Type III Alpha 1 Chain) • SMAD7 (SMAD Family Member 7) • TAGLN (Transgelin) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • AKAP12 (A-Kinase Anchoring Protein 12) • RGS2 (Regulator Of G Protein Signaling 2) • NCOA1 (Nuclear Receptor Coactivator 1)
    2ms
    Retraction Note. (PubMed, Eur Rev Med Pharmacol Sci)
    These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.
    Journal
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    MMP2 (Matrix metallopeptidase 2) • KDM6B (Lysine Demethylase 6B) • TWIST1 (Twist Family BHLH Transcription Factor 1) • AQP1 (Aquaporin 1) • MIR132 (MicroRNA 132) • MIR216A (MicroRNA 216a) • MIR25 (MicroRNA 25) • RUNX2 (RUNX Family Transcription Factor 2)
    2ms
    Multi-Target Effects of Novel Synthetic Indanedione-Based Spirotransdicalinol Compound 4l in Autosomal Dominant Polycystic Kidney Disease. (PubMed, FASEB J)
    Tolvaptan is the only FDA-approved drug to treat ADPKD, which has significant side effects, prompting the need for safer novel treatments...4l's efficiency across 2D, 3D, and iPSC-derived models highlights its therapeutic potential. This study also recognizes mitophagy and necroptosis as novel targets in ADPKD and corroborates iPSC-derived renal cells as a powerful platform for drug screening.
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    RB1 (RB Transcriptional Corepressor 1) • AQP1 (Aquaporin 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GATA3 (GATA binding protein 3) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) • TGFB2 (Transforming Growth Factor Beta 2)
    2ms
    Rhapontigenin Suppresses Leptin-Induced Vasculogenic Mimicry by Inhibiting STAT3-Aquaporin-1 Axis in TNBC Cells. (PubMed, Biomedicines)
    Consistent with these effects, the expression levels of invasion- and VM-related proteins and matrix metalloproteinase-2 activity were increased by leptin, which was reduced after Rha treatment. These results indicate that Rha inhibits invasive behavior and VM in TNBC cells by interfering with the leptin-STAT3-AQP1 signaling pathway, suggesting that Rha is a promising therapeutic candidate for the treatment of obesity-associated TNBC.
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • MMP2 (Matrix metallopeptidase 2) • AQP1 (Aquaporin 1) • LEP (Leptin)
    2ms
    TRPV4 Orchestrates Distinct Calcium and Cell Growth Responses in Non-Tumorigenic and Clear Cell Renal Carcinoma-Derived Cells. (PubMed, J Cell Physiol)
    These findings suggest that TRPV4 contributes to ccRCC progression by modulating calcium dynamics, subcellular organization, and tumor cell behavior. Taken together, our findings position TRPV4 as a functionally relevant ion channel in ccRCC, supporting its further exploration as a therapeutic target in renal cancer.
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    AQP1 (Aquaporin 1)
    2ms
    A Streptozotocin-Induced Mouse Model of Renal Tumors: Histopathological and Immunohistochemical Comparisons With Human Chromophobe Renal Cell Carcinoma. (PubMed, Toxicol Pathol)
    Furthermore, the tumors expressed collecting duct markers (uromodulin, CD15, MUC1, and GLUT-1) but lacked proximal convoluted tubule markers (AQP1 and megalin), suggesting a collecting duct origin. Taken together, STZ-induced mouse renal tumors closely resemble human chRCC, providing a reproducible model for investigating the biology and potential therapeutic approaches for this tumor type.
    Preclinical • Journal
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • MUC1 (Mucin 1) • CDH1 (Cadherin 1) • VIM (Vimentin) • MME (Membrane Metalloendopeptidase) • AQP1 (Aquaporin 1) • PAX8 (Paired box 8) • SLC2A1 (Solute Carrier Family 2 Member 1)
    2ms
    Relative biological effectiveness and neural stem cell fate in carbon ion-irradiated human brain organoids. (PubMed, Radiother Oncol)
    Our findings indicate that aberrant CP development is a central mechanism underlying post-radiation contrast-enhanced brain lesions, and that an RBE of 2 should be considered when determining dose thresholds for normal tissue tolerance in carbon ion therapy for brain tumors.
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    AQP1 (Aquaporin 1) • CLDN3 (Claudin 3)