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DRUG:

drozitumab (RG7425)

i
Other names: RG7425, PRO95780
Associations
Company:
Roche
Drug class:
TRAIL R2 agonist
Associations
over2years
The RNA-binding protein La/SSB associates with radiation-induced DNA double-strand breaks in lung cancer cell lines. (PubMed, Cancer Rep (Hoboken))
The co-localisation of La/SSB with radiation-induced DNA breaks suggests a role of La/SSB in DNA repair, however further experimentation is required to validate this.
Preclinical • Journal
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RAD51 (RAD51 Homolog A)
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drozitumab (RG7425)