^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    APOBEC3B deletion

    i
    Other names: APOBEC3B, Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B, PHRBNL, Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3B, DNA DC->DU-Editing Enzyme APOBEC-3B, Phorbolin-1-Related Protein, Phorbolin-2/3, Phorbolin 3, FLJ21201, A3B, Probable DNA DC->DU-Editing Enzyme APOBEC-3b, Cytidine Deaminase, Phorbolin 2, DJ742C19, BK150C2.2, APOBEC1L, ARCD3, ARP4
    Entrez ID:
    9582
    Related biomarkers:
    Expression
    over2years
    The APOBEC3B c.783delG Truncating Mutation Is Not Associated with an Increased Risk of Breast Cancer in the Polish Population. (PubMed, Genes (Basel))
    We conclude the APOBEC3B deleterious mutation p.Val262Phefs does not confer breast cancer risk. These data do not support the hypothesis that APOBEC3B is a breast cancer susceptibility gene.
    Journal
    |
    APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B)
    |
    APOBEC3B deletion
    3years
    Prognostic value of an APOBEC3 deletion polymorphism for glioma patients in Taiwan. (PubMed, J Neurosurg)
    The germline APOBEC3 deletion was associated with increased GBM risk and better OS in astrocytic glioma patients in the Taiwan male population. The APOBEC3B deletion homozygote was a potential independent prognostic factor predicting better survival in male astrocytic glioma patients.
    Journal
    |
    APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B)
    |
    APOBEC3B deletion
    over3years
    Mechanisms of APOBEC3 mutagenesis in human cancer cells. (PubMed, Nature)
    Together, these data represent direct evidence that endogenous APOBEC3 deaminases generate prevalent mutational signatures in human cancer cells. Our results identify APOBEC3A as the main driver of these mutations, indicate that APOBEC3B can restrain APOBEC3A-dependent mutagenesis while contributing its own smaller mutation burdens and dissect mechanisms that translate APOBEC3 activities into distinct mutational signatures.
    Journal • Tumor Mutational Burden
    |
    TMB (Tumor Mutational Burden) • APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B)
    |
    APOBEC3B deletion