^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    APEX2 (Apurinic/Apyrimidinic Endodeoxyribonuclease 2)

    i
    Other names: APEX2, Apurinic/Apyrimidinic Endodeoxyribonuclease 2, APEXL2, APE2, XTH2, APEX Nuclease (Apurinic/Apyrimidinic Endonuclease) 2, DNA-(Apurinic Or Apyrimidinic Site) Endonuclease 2, Zinc Finger, GRF-Type Containing, AP Endonuclease XTH2, AP Endonuclease, ZGRF2, DNA-(Apurinic Or Apyrimidinic Site) Lyase, Apurinic/Apyrimidinic Endonuclease-Like, Apurinic-Apyrimidinic Endonuclease, APEX Nuclease-Like, APEX Nuclease
    almost4years
    Proteome analysis of nuclear Lipid-Associated Promyelocytic Leukemia (PML) Structures (LAPS) Using Biotin Proximity Labelling. (PubMed, FASEB J)
    The COPII pathway has previously been implicated in protein delivery to cytoplasmic LD setting a precedence for the interaction we observed with LAPS. Thus, given our preliminary data showing interaction between Sec 23/24 heterodimer, PML-NBs and LAPS we are now pursuing the hypothesis that lipid membrane deformation and/or cargo transport activity in the nucleus by COPII proteins could play a role in lipid homeostasis.
    Journal
    |
    APEX2 (Apurinic/Apyrimidinic Endodeoxyribonuclease 2) • DAXX (Death-domain associated protein) • SEC23IP (SEC23 Interacting Protein)