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    GENE:

    APBB1 (Amyloid Beta Precursor Protein Binding Family B Member 1)

    i
    Other names: APBB1, Amyloid Beta Precursor Protein Binding Family B Member 1, RIR, Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65), Fe65, FE65, Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1, Adaptor Protein FE65a2, Stat-Like Protein, Protein Fe65, MGC:9072
    over1year
    Identification of APPB1 as a substrate for anaplastic lymphoma kinase. (PubMed, J Biochem)
    In conclusion, we successfully identified a new substrate for receptor ALK. Our results may help further elucidate the molecular mechanism of ALK downstream signaling in neuroblastoma.
    Journal
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    ALK (Anaplastic lymphoma kinase) • APP (Amyloid Beta Precursor Protein) • APBB1 (Amyloid Beta Precursor Protein Binding Family B Member 1)
    over3years
    Exploration of hub genes, lipid metabolism, and the immune microenvironment in stomach carcinoma and cholangiocarcinoma. (PubMed, Ann Transl Med)
    APBB1, ARMCX1, DZIP1, and MSRB3 affect the development of GC and CCA and can be used as biomarkers. The expression of lipid metabolism genes is related to the TIME of patients with GC and CCA.
    Journal
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    APP (Amyloid Beta Precursor Protein) • APBB1 (Amyloid Beta Precursor Protein Binding Family B Member 1)
    over3years
    FE65 defines the efficacy of tamoxifen treatment via osteopontin expression in estrogen receptor-positive breast cancer. (PubMed, Pathol Res Pract)
    We firstly demonstrated the clinicopathological significance of FE65 in ER-positive breast cancer patients and results indicated that the effects of FE65 on ER-positive breast cancer patients were mediated through OPN expression. In addition, results suggested the clinical value of FE65 as potential prognostic factor and surrogate marker of TAM therapy in ER-positive breast cancer patients.
    Journal
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    ER (Estrogen receptor) • SPP1 (Secreted Phosphoprotein 1) • APBB1 (Amyloid Beta Precursor Protein Binding Family B Member 1)
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    ER positive • ER expression
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    tamoxifen