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    DRUG:

    AP-3-84

    i
    Other names: AP-3-84
    Associations

    News

    Trials
    Company:
    The Wistar Institute
    Drug class:
    Rb1 protein modulator
    Associations

    News

    Trials
    almost3years
    Targeting acute myeloid leukemia cell death via small molecule AP-3-84 binding to the LxCxE pocket of Rb1 (AACR 2023)
    We identify a new small molecule, AP-3-84, with therapeutic potential in AML by its binding to the LxCxE pocket of Rb1 triggering mitochondria-mediated cell apoptosis.
    PARP Biomarker
    |
    RB1 (RB Transcriptional Corepressor 1) • CASP3 (Caspase 3) • ATF4 (Activating Transcription Factor 4) • GLI2 (GLI Family Zinc Finger 2) • ANXA5 (Annexin A5) • ATF3 (Activating Transcription Factor 3)
    |
    RB1 expression
    |
    AP-3-84