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GENE:

ANXA3 (Annexin A3)

News alerts, weekly reports and conference planners

4ms

Mechanistic study of ANXA3-mediated endoplasmic reticulum stress promoting M1 macrophage polarization in pulmonary arterial hypertension based on bioinformatics and nine machine learning algorithms. (PubMed, Comput Biol Med)

This study demonstrates that ANXA3 regulates ERS to drive M1 macrophage polarization and inflammation, which subsequently promotes PASMC function and promotes PAH progression. ANXA3 may serve as a novel immunoinflammatory target and potential therapeutic candidate.

4 months ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • BCL2L1 (BCL2-like 1) • TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF17 (TNF Receptor Superfamily Member 17) • CD68 (CD68 Molecule) • IL18 (Interleukin 18) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF4 (Activating Transcription Factor 4) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • IL1B (Interleukin 1, beta) • ANXA3 (Annexin A3) • TCF4 (Transcription Factor 4)

semaxanib (SU5416)

6ms

Shared diagnostic genes and potential mechanisms between asthma and lung cancer revealed by integrated transcriptomic analysis and machine learning. (PubMed, Eur J Transl Myol)

Utilizing machine learning-based screening, we identified three hub biomarkers: P2RY14, ANXA3, and SLIT2, which could serve as diagnostic tools for these diseases. In summary, our research provides invaluable insights into the shared mechanisms underlying asthma and lung cancer, and potential diagnostic biomarkers.

6 months ago

Journal

SLIT2 (Slit Guidance Ligand 2) • ANXA3 (Annexin A3)

6ms

Assessing the role of Escherichia coli and Klebsiella pneumoniae in colorectal cancer oncogene expression: insights from microbial colonization phenotypes. (PubMed, Mol Biol Rep)

Our findings indicate that E. coli and K. pneumoniae may exert nuanced, tumor-specific effects on oncogenic pathways, potentially mediated more by chronic inflammation than direct gene dysregulation. Further studies employing single-cell RNA sequencing are warranted to elucidate these interactions and their translational potential for CRC diagnostics and therapeutics.

6 months ago

Journal

MAP2K1 (Mitogen-activated protein kinase kinase 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • FOLH1 (Folate hydrolase 1) • TGFB1 (Transforming Growth Factor Beta 1) • ANXA3 (Annexin A3)

8ms

Integrated proteomic and targeted Next Generation Sequencing reveal relevant heterogeneity in lower-grade meningioma and ANXA3 as a new target in NF2 mutated meningiomas. (PubMed, EBioMedicine)

These findings highlight new targets in different meningioma backgrounds, presenting ANXA3 as a potential therapeutic target for meningioma treatment.

8 months ago

Journal • Next-generation sequencing

AKT1 (V-akt murine thymoma viral oncogene homolog 1) • NF2 (Neurofibromin 2) • KLF4 (Kruppel-like factor 4) • ANXA3 (Annexin A3)

AKT1 mutation

10ms

Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies. (PubMed, BMC Cancer)

A five biomarker panel can server as complementary biomarker to CEA and CA19-9 in CRC detection.

10 months ago

Journal

NPM1 (Nucleophosmin 1) • ACTG1 (Actin Gamma 1) • ANXA3 (Annexin A3) • CA 19-9 (Cancer antigen 19-9) • EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1)

11ms

FOXD1-activated ANXA3 facilitates cisplatin resistance of lung cancer cells via promoting ANXA4 expression. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)

Also, ANXA3 silencing could reduce lung cancer tumorigenesis and enhance DDP sensitivity by decreasing ANXA4 expression in vivo. ANXA3, activated by FOXD1, might contribute to the DDP resistance of lung cancer via regulating ANXA4, providing new ideas for overcoming chemoresistance in lung cancer.

11 months ago

Journal

FOXD1 (Forkhead Box D1) • ANXA3 (Annexin A3)

cisplatin

12ms

Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer. (PubMed, J Med Chem)

In particular, 18a5 showed more desirable ANXA3 selective degradation than (R)-SL18 and displayed excellent inhibitory effect in a TNBC tumor xenograft model (TGI = 96%). Collectively, 18a5 proved to be a promising lead compound to treat TNBC through the degradation of ANXA3.

12 months ago

Journal

ANXA3 (Annexin A3)

12ms

Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis. (clinicaltrials.gov)

P=N/A, N=200, Not yet recruiting, Chinese University of Hong Kong

12 months ago

New trial

IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IFI27 (Interferon Alpha Inducible Protein 27) • ALPL (Alkaline Phosphatase) • ANKRD22 (Ankyrin Repeat Domain 22) • ANXA3 (Annexin A3) • ATF3 (Activating Transcription Factor 3)

1year

Identification of neutrophil extracellular traps (NETs)-related molecular clusters in prostate cancer: Implications for predicting biochemical recurrence. (PubMed, Int Immunopharmacol)

We have identified novel NETs-related clusters and developed a NETs-related model for PCa that has excellent predictive performance for predicting biochemical recurrences as well as chemotherapy efficacy.

1 year ago

Journal

ANXA3 (Annexin A3)

over1year

Data-driven analysis that integrates bioinformatics and machine learning uncovers PANoptosis-related diagnostic genes in early pediatric septic shock. (PubMed, Heliyon)

In summary, the discovery of PANoptosis genes, ANXA3, S100A9, TXN, CLEC5A, and TMEM263 proved to be quite helpful in the early detection of pediatric septic shock patients. These early results, which need to be further confirmed in basic and clinical research, are extremely important for understanding immune cell infiltration in the pathophysiology of pediatric septic shock.

over 1 year ago

Journal • Machine learning

S100A9 (S100 Calcium Binding Protein A9) • ANXA3 (Annexin A3) • CLEC5A (C-Type Lectin Domain Containing 5A)

over1year

Proteomic heterogeneity of the extracellular matrix identifies histologic subtype-specific fibroblast in gastric cancer. (PubMed, Mol Cell Proteomics)

Using tumor microarray analysis, we confirmed the CAFadi surface marker, ATP binding cassette subfamily A member 8 (ABCA8), predominantly present in PCC-NOS tumors. Our ECM-focused analysis paves the way for studies to determine their utility as biomarkers for patient stratification, offering valuable insights for linking molecular and histologic features in GC.

over 1 year ago

Journal

SERPINH1 (Serpin family H member 1) • ANXA3 (Annexin A3) • MMP14 (Matrix Metallopeptidase 14) • S100A6 (S100 calcium binding protein A6)

over1year

Revealing Cellular Heterogeneity and Key Regulatory Factors of Triple-Negative Breast Cancer through Single-Cell RNA Sequencing. (PubMed, Front Biosci (Landmark Ed))

The four epithelial cell subsets and two critical regulons identified based on the scRNA-seq data could help explore the underlying intratumoral heterogeneity molecular mechanism and develop effective therapies for TNBC.

over 1 year ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • MKI67 (Marker of proliferation Ki-67) • XBP1 (X-box-binding protein 1) • ANXA3 (Annexin A3) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2) • SCD (Stearoyl-CoA Desaturase)