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ANPEP (Alanyl Aminopeptidase, Membrane)

News alerts, weekly reports and conference planners

Chronic stress-induced ANPEP drives liver cancer progression by increasing glutathione synthesis and inhibiting ferroptosis. (PubMed, J Clin Invest)

The combination of ANPEP silencing and sorafenib treatment showed a synergistic effect in inhibiting liver cancer progression. Finally, clinical data and mouse models demonstrated that chronic stress drove liver tumor progression via ANPEP-regulated SLC3A2. These findings reveal unanticipated communication between chronic stress and metabolic reprogramming during liver cancer progression, providing potential therapeutic implications for liver cancer.

4 days ago

Journal

SLC3A2 (Solute Carrier Family 3 Member 2) • ANPEP (Alanyl Aminopeptidase, Membrane)

sorafenib

12d

Immunophenotypic patterns in paediatric acute leukaemia: A flowcytometry-based prospective observational study in tribal dominant state, Jharkhand. (PubMed, J Family Med Prim Care)

Flow cytometry is a highly accurate tool for differentiating leukaemia subtypes. Immunophenotyping plays a crucial role in diagnosis, classification, and treatment planning for Paediatric leukaemia.

12 days ago

Observational data • Journal

CD33 (CD33 Molecule) • CD5 (CD5 Molecule) • CD79A (CD79a Molecule) • MME (Membrane Metalloendopeptidase) • CD7 (CD7 Molecule) • ANPEP (Alanyl Aminopeptidase, Membrane)

20d

Clinical Characteristics and Diagnosis of Children t(8; 21)/AML1-ETO Positive Acute Myeloid Leukemia with Basophilic Granulocytosis. (PubMed, Clin Lab)

AML1-ETO fusion gene positive acute myeloid leukemia with basophilic granulocytosis is a rare type of leukemia, and its pathogenesis, diagnosis, treatment, and prognosis are unique. In-depth study of such cases, combined with the review of relevant literature, is helpful to further reveal the pathogenesis of leukemia, provide more evidence for clinical diagnosis and treatment, so as to improve the level of diagnosis and treatment and improve the prognosis of patients.

20 days ago

Journal • IO biomarker

KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD19 (CD19 Molecule) • CD38 (CD38 Molecule) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • CD7 (CD7 Molecule) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • ANPEP (Alanyl Aminopeptidase, Membrane) • FUT4 (Fucosyltransferase 4)

CD20 positive • CD33 positive

22d

Clinical Characteristics of Adult Acute Myeloid Leukemia Patients with NUP98::HOXA9 Fusion Gene (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)

The most common type of NUP98 rearrangement in adults AML patients is NUP98::HOXA9 , which is often accompanied by somatic mutations in WT1, TET2, and FLT3-ITD. These patients are prone to relapse, have short survival time, and generally face poor prognoses. Hopefully, utilization of the AZA+VEN regimen is anticipated to enhance the rate of induced remission in the patients, and some patients may prolong their survival through allo-HSCT. However, more effective treatment methods are still needed to improve the overall prognosis of these patients.

22 days ago

Journal • IO biomarker

KRAS (KRAS proto-oncogene GTPase) • FLT3 (Fms-related tyrosine kinase 3) • NRAS (Neuroblastoma RAS viral oncogene homolog) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • CD38 (CD38 Molecule) • WT1 (WT1 Transcription Factor) • NUP98 (Nucleoporin 98 And 96 Precursor 2) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • HOXA9 (Homeobox A9) • ANPEP (Alanyl Aminopeptidase, Membrane)

KRAS mutation • NRAS mutation • FLT3-ITD mutation • TET2 mutation

Venclexta (venetoclax) • azacitidine

26d

Understanding the Role of All-Trans Retinoic Acid in Acute Myeloid Leukemia Cells. (PubMed, World J Oncol)

This integrative profiling - linking molecular, functional, and morphological parameters - offers a nuanced understanding of the differentiation trajectory and establishes a robust framework for assessing ATRA and other differentiation-based strategies in AML. By delineating these correlations, our findings pave the way for therapeutic approaches that leverage controlled leukemic cell maturation, potentially minimizing the cytotoxic burden associated with conventional chemotherapy.

26 days ago

Journal • IO biomarker

RUNX1 (RUNX Family Transcription Factor 1) • CD38 (CD38 Molecule) • CD33 (CD33 Molecule) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • ITGAM (Integrin, alpha M) • ANPEP (Alanyl Aminopeptidase, Membrane) • FUT4 (Fucosyltransferase 4)

Liver Cancer Bone Metastasis: Molecular Mechanisms and Therapeutic Insights. (PubMed, Curr Top Med Chem)

These insights highlighted the complexity of liver cancer bone metastasis, and suggested potential therapeutic strategies targeting EMT, LCSCs, and OB-OC-CSC crosstalk. Future studies are encouraged to validate marker functions in clinical cohorts, elucidate dormancy-exit mechanisms, and explore immunomodulatory interventions to overcome microenvironment-mediated resistance.

1 month ago

Journal

SPP1 (Secreted Phosphoprotein 1) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • EPCAM (Epithelial cell adhesion molecule) • GAS6 (Growth arrest specific 6) • THY1 (Thy-1 membrane glycoprotein) • ANPEP (Alanyl Aminopeptidase, Membrane)

Oligodendroglia Generate Vascular Mural Cells and Neurons in the Adult Mouse Brain. (PubMed, Biol Pharm Bull)

We compared the effect of tamoxifen dissolved in different solvents on the fate of Sox10 cells...This investigation provides evidence that a substantial proportion of oligodendroglia in the grey matter serve as mural cell precursors and neuronal precursors. These two phenomena may contribute to our understanding of the fate of oligodendroglia.

1 month ago

Preclinical • Journal

PDGFRB (Platelet Derived Growth Factor Receptor Beta) • SOX10 (SRY-Box 10) • HMGB1 (High Mobility Group Box 1) • MYH11 (Myosin Heavy Chain 11) • ANPEP (Alanyl Aminopeptidase, Membrane)

tamoxifen

2ms

Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM) (clinicaltrials.gov)

P1, N=44, Active, not recruiting, Baylor College of Medicine | Recruiting --> Active, not recruiting

2 months ago

Enrollment closed

KIT (KIT proto-oncogene, receptor tyrosine kinase) • WT1 (WT1 Transcription Factor) • CD33 (CD33 Molecule) • ANPEP (Alanyl Aminopeptidase, Membrane)

MultiTAA T cell therapy

2ms

The Clinical Significance of CD371 Expression Detected by Flow Cytometry in Primary Myelofibrosis. (PubMed, Int J Lab Hematol)

This study provides the first characterization of CD371 expression patterns in PMF, showing significantly different expression profiles compared to controls. While CD371 demonstrated comparable performance to standard markers (CD34/CD38/CD13/CD33) and showed better discrimination than CD123/HLA-DR, these preliminary findings suggest its potential utility for: (1) identifying abnormal CD34+CD117+ populations in PMF, and (2) possible integration into routine clinical workflows, pending further validation in larger cohorts.

2 months ago

Journal • IO biomarker

KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD38 (CD38 Molecule) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • CD7 (CD7 Molecule) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • CD37 (CD37 Molecule) • ANPEP (Alanyl Aminopeptidase, Membrane)

2ms

Dynamic profiles of 25 serum biomarkers in acute myocardial infarction. (PubMed, Front Cardiovasc Med)

They returned to baseline levels at 12 h and 2 h respectively, followed by rapid decreases again. This study is the first to systematically characterize the dynamic profiles of 25 serum biomarkers following AMI in rats, revealing that: (1) IL-1β, S100A8, BNP, SLC31A1 and Cys may serve as an ultra-early (1 h) diagnostic panel (increase of over 70% at 1 h); (2) the delayed elevation of α-SMA and CXCL16 may be associated with the initiation of myocardial repair; (3) the suppression of Lp-α and D2D might reflect compensatory protective mechanisms.

2 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • S100A8 (S100 Calcium Binding Protein A8) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • CCL2 (Chemokine (C-C motif) ligand 2) • MMP9 (Matrix metallopeptidase 9) • CCR2 (C-C Motif Chemokine Receptor 2) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ANPEP (Alanyl Aminopeptidase, Membrane) • CRP (C-reactive protein) • CTGF (Connective tissue growth factor) • CXCL16 (C-X-C Motif Chemokine Ligand 16) • DRD2 (Dopamine Receptor D2) • SLC31A1 (Solute Carrier Family 31 Member 1)

2ms

Aminopeptidase N (CD13): Bridging physiology, pathology and therapeutic potential. (PubMed, Adv Clin Chem)

This chapter comprehensively reviews this protein with the aim of improving current understanding of this protein, with a particular focus on its tissue-specific expression and functional roles. Special attention is given to the physiological and pathological diversity of CD13 activity, which offers critical insights into opportunities for selective targeting and disease-specific therapeutic applications.

2 months ago

Review • Journal

ANPEP (Alanyl Aminopeptidase, Membrane)

3ms

Primary Acute Myeloid Leukemia with Concomitant BCR∷ABL and NPM1 Mutation. (PubMed, Clin Lab)

AML with BCR∷ABL cases are relatively rare, and the establishment of standardized diagnostic and treatment strategies is still lacking. Our research findings emphasize the importance of including BCR∷ABL detection in the diagnostic examination of AML to enable the provision of the most appropriate risk classification and treatment options for patients.

3 months ago

Journal • IO biomarker

ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • NPM1 (Nucleophosmin 1) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CD38 (CD38 Molecule) • KMT2C (Lysine Methyltransferase 2C) • NOTCH2 (Notch 2) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD33 (CD33 Molecule) • NCAM1 (Neural cell adhesion molecule 1) • ITGAM (Integrin, alpha M) • CD7 (CD7 Molecule) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • USH2A (Usherin) • ANPEP (Alanyl Aminopeptidase, Membrane)

NPM1 mutation

Venclexta (venetoclax) • dasatinib • azacitidine