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BIOMARKER:

ANGPT2 expression

i
Other names: ANGPT2, Ang2, Angiopoietin 2
Entrez ID:
Related biomarkers:
16d
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. (PubMed, Cancer Gene Ther)
We conclude that ANGPTL2-mediated stromal cell crosstalk facilitates anti-tumor immunity and ICI responsiveness. These findings overall provide novel insight into ANGPTL2 anti-tumor function and regulation of ICI-induced anti-tumor immunity.
Journal • Checkpoint inhibition • IO biomarker • Stroma
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CD8 (cluster of differentiation 8) • ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
5ms
Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment. (PubMed, J Clin Invest)
These changes were accompanied by reduced plasma leakage and improved vascular integrity in metastases. Together, these findings suggest that ANGPT2 blockade may be an effective strategy for promoting T cell infiltration and immunostimulatory reprogramming to reduce the growth of liver metastases in PanNETs.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
6ms
DCE-MRI-based radiomics in predicting angiopoietin-2 expression in hepatocellular carcinoma. (PubMed, Abdom Radiol (NY))
The DCE-MRI-based radiomics model has the potential to predict Ang-2 expression in HCC patients; the combined model integrating the radiomics score with CR factors can further improve the prediction performance.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
8ms
Angiopoietin-2 expression and its relationship with lymphangiogenesis and clinicopathological characteristics in cutaneous malignant melanoma. (PubMed, Front Oncol)
An evaluation of Ang-2 expression and LVD can be used to predict the risk of tumor lymphatic metastasis and determine the prognosis of CMM. These results may also provide a new clinical treatment strategy for CMM.
Journal
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ANGPT2 (Angiopoietin 2) • FLT4 (Fms-related tyrosine kinase 4) • LYVE1 (Lymphatic vessel endothelial hyaluronan receptor 1)
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ANGPT2 expression
8ms
Angiogenetic Factors Predict Clinical Outcome In Endometrial Cancer (ESGO 2023)
Additionally, PDGFRA (DSS HR 3.164) and PDGFB (OS HR 1.565) proved to be predictive markers in Cox regression analyses. The expression of PDGFRA and PDGFRB was significantly different between the PROMISE molecular subtypes.Conclusion Various angiogenetic molecules influence the clinical prognosis and their predictive value should be evaluated for anti-angiogenetic therapy.
Clinical • Clinical data
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • KDR (Kinase insert domain receptor) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • ANGPT2 (Angiopoietin 2) • FGF2 (Fibroblast Growth Factor 2) • PDGFA (Platelet Derived Growth Factor Subunit A) • PDGFB (Platelet Derived Growth Factor Subunit B)
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ANGPT2 expression
9ms
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas. (PubMed, Proc Natl Acad Sci U S A)
However, combination therapy with anti-VEGF and anti-ANG2 drugs produced synergistic and potent anticancer effects in KRAS-mutated cancers. Together, these data demonstrate that KRAS mutations in tumors serve as a predictive marker for anti-VEGF resistance and are susceptible to combination therapy with anti-VEGF and anti-ANG2 drugs.
Journal
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KRAS (KRAS proto-oncogene GTPase) • ANGPT2 (Angiopoietin 2)
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KRAS mutation • ANGPT2 elevation • ANGPT2 expression
1year
ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis. (PubMed, Aging (Albany NY))
Importantly, overexpression ANGPTL2 facilitated tumor growth and lymphangiogenesis in vivo. Thus, ANGPTL2 is a promising therapeutic object for treating lung cancer.
Journal
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VEGFA (Vascular endothelial growth factor A) • ANGPT2 (Angiopoietin 2)
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ANGPT2 expression • ANGPT2 overexpression
1year
Homeobox D9 drives the malignant phenotypes and enhances the Programmed death ligand-1 expression in non-small cell lung cancer cells via binding to Angiopoietin-2 promoter. (PubMed, World J Surg Oncol)
Forced expression of ANGPT2 significantly regulated HOXD9-mediated malignant phenotypes, and enhanced PD-L1 expression of NSCLC cells. Our results expressing HOXD9 may function as an oncogene in NSCLC via trans-activation of ANGPT2.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • ANGPT2 (Angiopoietin 2)
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PD-L1 expression • ANGPT2 expression
1year
Vascular regulation of T-cell exclusion in melanoma (AACR 2023)
Therapeutic response after ANGPT2 blockade, driven by improved CD8+ T-cell infiltration, coincided with TIE2 signaling activation and increased vascular integrity in the tumor periphery, indicating that maintenance of vascular integrity within tumors is necessary for robust response to immunotherapy. These data highlight ANGPT2/TIE2 signaling as a key mediator of T-cell exclusion and a promising target to potentiate checkpoint inhibitor efficacy in melanoma.
PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • ANGPT2 (Angiopoietin 2)
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ANGPT2-L • ANGPT2 elevation • ANGPT2 expression
1year
Helicobacter pylori infection induces abnormal expression of pro-angiogenic gene ANGPT2 and miR-203a in AGS gastric cell line. (PubMed, Braz J Microbiol)
Our results suggest that H. pylori could contribute to the process of carcinogenesis by downregulating miR-203a, which further promotes angiogenesis in gastric mucosa by increasing ANGPT2 expression. Further investigation is needed to elucidate the underlying molecular mechanisms.
Preclinical • Journal
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ANGPT2 (Angiopoietin 2) • MIR200A (MicroRNA 200a) • MIR203A (MicroRNA 203a)
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ANGPT2 expression
1year
Helicobacter pylori infection induces gastric precancerous lesions and persistent expression of Angpt2, Vegf-A and Tnf-A in a mouse model. (PubMed, Front Oncol)
Our data show that H. pylori infection induces the expression of Angpt2, Tnf-A and Vegf-A in murine gastric epithelium. This may contribute to the pathogenesis of H. pylori-associated gastritis, however the significance of this should be further addressed.
Preclinical • Journal
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VEGFA (Vascular endothelial growth factor A) • TNFA (Tumor Necrosis Factor-Alpha) • ANGPT2 (Angiopoietin 2)
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VEGFA expression • ANGPT2 expression
over1year
Immunoregulation and clinical significance of neutrophils/NETs-ANGPT2 in tumor microenvironment of gastric cancer. (PubMed, Front Immunol)
In conclusion, NETs promoted ANGPT2 overexpression in the GC microenvironment. In the future, the neutrophil/NETs-ANGPT2 axis may provide a new target for the treatment of GC.
Journal • IO biomarker
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression • ANGPT2 overexpression
over1year
Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis. (PubMed, World J Gastroenterol)
There is a significant difference in overall survival between HCC patients with high and low expression of ANGPT2, PGF, VEGFA, and VEGFD. Disease free survival (DFS) is significantly shorter in HCC patients with high ANGPT2, PGF, and VEGFA expression than in those with low ANGPT2, PGF, and VEGFA expression.
Journal
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ANGPT2 (Angiopoietin 2) • VEGFD (Vascular Endothelial Growth Factor D) • VEGFB (Vascular Endothelial Growth Factor B) • VEGFC (Vascular Endothelial Growth Factor C)
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ANGPT2-L • VEGFA expression • ANGPT2 expression
over1year
Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation. (PubMed, Front Oncol)
Endothelial angiopoietin-2 expression is a powerful independent predictor of post-LT tumor recurrence and mortality, highlighting the fundamental role of tumor biology in defining the patients' prognosis after liver transplantation. The great advantage of endothelial angiopoietin-2 is that it is evaluable in HCC biopsy before LT and could drive a patient's priority on the waiting list.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
over1year
MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma. (PubMed, Cell Death Dis)
Importantly, we confirmed the correlation between MYBL1 and ANGPT2 expression in a large cohort of clinical HCC samples and several published datasets in pancreatic cancer, esophageal carcinoma, stomach adenocarcinoma, and colon cancer. Our results demonstrate that MYBL1 upregulated the ANGPT2 expression, then induced angiogenesis and confer sorafenib resistance to HCC cells, and MYBL1 may represent a novel prognostic biomarker and therapeutic target for patients with HCC.
Journal
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ANGPT2 (Angiopoietin 2) • PRMT5 (Protein Arginine Methyltransferase 5) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • WDR5 (WD Repeat Domain 5) • MYBL1 (MYB Proto-Oncogene Like 1)
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ANGPT2 expression
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sorafenib
over1year
Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis. (PubMed, Oncogene)
Moreover, our observations support a model whereby ANGPTL2-induced OB-cadherin expression in CRC cells is accompanied by decreased cell surface integrin α5β1 expression. These findings overall provide novel insight into mechanisms of β-catenin-driven intestinal tumorigenesis.
Journal
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CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
over1year
HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway. (PubMed, Exp Ther Med)
Furthermore, ANGPT2 silencing inactivated ERK/AKT signaling, whereas the HOXB5 overexpression blocked this effect. In conclusion, ANGPT2, which was transcriptionally activated by HOXB5, activated the ERK/AKT signaling pathway to promote proliferation, metastasis and angiogenesis of esophageal cancer cells.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
over1year
The Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma. (PubMed, Biomedicines)
In a mouse model of OSCC, CCL4-treated cells promoted neovascularization in implanted Matrigel plugs, whereas inhibiting CCL4 expression suppressed Angpt2 expression and angiogenesis. CCL4 shows promise as a new molecular therapeutic target for inhibiting angiogenesis and metastasis in OSCC.
Journal
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ANGPT2 (Angiopoietin 2) • CCL4 (Chemokine (C-C motif) ligand 4)
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ANGPT2 expression
almost2years
Gastric Cancer-Derived Extracellular Vesicles (EVs) Promote Angiogenesis via Angiopoietin-2. (PubMed, Cancers (Basel))
Our data suggest a new mechanism via which GC cells induce angiogenesis. This knowledge may be utilized to develop new therapies in gastric cancer.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
almost2years
The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2. (PubMed, Oncogene)
Mechanistically, in addition to AA, immune-depletion of ANGPT2 from secretome or blocking ANGPT2-receptors inhibits androgen-induced angiogenesis. Taken together, we reveal a VEGF-independent ANGPT2-mediated angiogenic pathway that is inhibited by AA leading to repression of androgen-regulated neo-angiogenesis.
Journal
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AR (Androgen receptor) • ANGPT2 (Angiopoietin 2)
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AR mutation • AR wild-type • ANGPT2 expression
almost2years
Ang-Tie Angiogenic Pathway Is Distinctively Expressed in Benign and Malignant Adrenocortical Tumors. (PubMed, Int J Mol Sci)
Tie1 expression was higher in ACC with venous invasion and in patients with shorter overall survival. In conclusion, although none of these biomarkers showed to be useful for ACT diagnosis, the Ang-Tie pathway is active in ACT and may play a role in regulating ACT angiogenesis.
Journal
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ANGPT2 (Angiopoietin 2) • CD34 (CD34 molecule)
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VEGFA expression • ANGPT2 expression
almost2years
Angpt2/Tie2 autostimulatory loop controls tumorigenesis. (PubMed, EMBO Mol Med)
Thus, the ANGPT2/TIE2 axis provides an exploitable therapeutic target in NF-PitNETs and possibly in other tumors expressing ANGPT2/TIE2. The ability of tumor cells to coopt angiogenic signals classically viewed as EC-specific expands our view on the microenvironmental cues that are essential for tumor progression.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 elevation • ANGPT2 expression
almost2years
Angiogenic factors as prognostic markers in neuroendocrine neoplasms. (PubMed, Endocrine)
We documented higher levels of angiogenic markers in NENs, with an association between ANG2 serum levels and NENs morphology and staging. In both GEP and lung NENs, ANG2 and PROK2 are higher in case of tumor progression, suggesting a potential role as prognostic markers in NENs patients.
Observational data • Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
2years
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of HIF-1α and ANGPT2. (PubMed, Int J Mol Sci)
In summary, miR-29a control HIF-1α and ANGPT2 signaling in HCC formation. This study insight into a novel molecular pathway by which miR-29a targeting HIF-1α and ANGPT2 counteracts the incidence of HCC development.
Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • ANGPT2 (Angiopoietin 2) • COL3A1 (Collagen Type III Alpha 1 Chain) • MIR29A (MicroRNA 29a)
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HIF1A expression • VEGFA expression • ANGPT2 expression
2years
Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model. (PubMed, Molecules)
Thus, Eg5 inhibitors appear to modulate angiogenic signalling by controlling VEGF activity even better if combined with HSD. Overall, Eg5 inhibitors can represent a promising starting point to develop innovative anti-cancer strategies.
Preclinical • Journal
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ANGPT2 (Angiopoietin 2) • MAPK1 (Mitogen-activated protein kinase 1)
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VEGFA expression • ANGPT2 expression
2years
Relationship between miR-204 and ANGPTL2 expression and diagnosis, pathological stage, and prognosis in patients with colon cancer. (PubMed, Transl Cancer Res)
Downregulating miR-204 expression plays a vital role in upregulating ANGPTL2 expression and promoting the pathogenesis of CRC. MiR-204 is able to hinder the proliferation of colorectal tumor cells and encourage apoptosis by targeting the inhibition of ANGPTL2 expression.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression • ANGPT2 overexpression
over2years
BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2. (PubMed, Aging (Albany NY))
In contrast, overexpression of BMAL1 promotes the expression of ANG2 and VEGF via HIF-1a pathway. Therefore, BMAL1 likely participates in the angiogenesis of glioma by modulating ANG2 and VEGF expression, alters the therapeutic effect of anti-angiogenic treatments, and promotes peritumoral brain edema of glioma.
Journal
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VEGFA (Vascular endothelial growth factor A) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • ANGPT2 (Angiopoietin 2) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like)
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HIF1A expression • VEGFA expression • ANGPT2 expression
over2years
The effect of Shendan Sanjie capsule on angiogenesis in mice with colitis associated cancer and mechanism (PubMed, Zhonghua Zhong Liu Za Zhi)
Ten mice were divided into the normal group, model group, Shendan Sanjie capsule group, MK-2206 group, and Shendan Sanjie capsule + IGF-1 group, respectively...The relative expression levels p-Akt/Akt, VEGFA and HIF-1α in colon cancer tissue of the Shendan Sanjie capsule+ IGF-1 group were 3.37±0.15, 4.02±0.11, 3.52±0.24, respectively, which were significantly higher than those in the Shendan Sanjie capsule group (P<0.05). Shendan Sanjie capsules may inhibit Akt/HIF-1α/VEGFA signaling pathway, and then reduce the expression of microvascular growth factors bFGF and Ang2, thereby inhibit the tumor angiogenesis of CAC.
Preclinical • Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • ANGPT2 (Angiopoietin 2) • IGF1 (Insulin-like growth factor 1)
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HIF1A expression • ANGPT2 expression
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MK-2206
almost3years
Fucoxanthin Exerts Anti-Tumor Activity on Canine Mammary Tumor Cells via Tumor Cell Apoptosis Induction and Angiogenesis Inhibition. (PubMed, Animals (Basel))
The results demonstrated that fucoxanthin exerted anti-angiogenic activity on HUVECs and CMT-U27 cells by promoting Ang2 expression. In conclusion, our results demonstrated that fucoxanthin induced tumor cell death and inhibited angiogenesis, suggesting that fucoxanthin could be considered as a promising therapeutic agent for canine mammary gland tumors.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
almost3years
miR‑135a‑5p inhibits tumor invasion by targeting ANGPT2 in gallbladder cancer. (PubMed, Mol Med Rep)
In conclusion, the present results suggested that miR‑135a‑5p affected GBC cell proliferation and invasion by targeting ANGPT2. Moreover, miR‑135a‑5p may be a potential biomarker for GBC progression and a potential target for GBC therapeutic intervention.
Journal
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ANGPT2 (Angiopoietin 2)
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ANGPT2 expression
almost3years
Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance. (PubMed, Biochem Biophys Res Commun)
In addition, we observed upregulation of anoikis (a form of programmed cell death occurring under an anchorage-independent condition) and significant decrease in the expression of Bcl-2 in ANGPTL2-expressing cells as compared to control cells. These results suggest that ANGPTL2 expression in ovarian cancer cells represses peritoneal metastasis by suppressing anoikis resistance.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • ANGPT2 (Angiopoietin 2)
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BCL2 expression • ANGPT2 expression
almost3years
Dual and opposing roles of the androgen receptor in VETC-dependent and invasion-dependent metastasis of hepatocellular carcinoma. (PubMed, J Hepatol)
AR plays dual and opposing roles in VETC-dependent and invasion-dependent metastasis, which highlights the complex functions of AR and the importance of individualized cancer therapy.
Journal
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AR (Androgen receptor) • ANGPT2 (Angiopoietin 2)
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AR overexpression • AR expression • ANGPT2 expression