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    DRUG CLASS:

    Angiopoietin 2 inhibitor

    Related drugs:
    9d
    M-VIVA: Identification of Molecular Signals in Vitreous Humor Associated With Suboptimal Response to Vascular Endothelial Growth Factor (VEGF) Inhibition in Neovascular Age-related Macular Degeneration (nAMD) Within a Clinical Trial Setting (clinicaltrials.gov)
    P=N/A, N=117, Recruiting, Singapore National Eye Centre
    New trial
    |
    CXCL8 (Chemokine (C-X-C motif) ligand 8)
    |
    Lucentis (ranibizumab)
    18d
    Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study) (clinicaltrials.gov)
    P=N/A, N=1000, Active, not recruiting, Hoffmann-La Roche | Trial primary completion date: Nov 2027 --> Nov 2026 | Recruiting --> Active, not recruiting
    Enrollment closed • Trial primary completion date • HEOR • Real-world evidence
    1m
    CONSTANCE: A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (clinicaltrials.gov)
    P4, N=274, Active, not recruiting, Hoffmann-La Roche | Recruiting --> Active, not recruiting | Trial completion date: Jan 2028 --> Sep 2027 | Trial primary completion date: Feb 2027 --> Oct 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    1m
    A Study of LY3127804 With Ramucirumab in Participants With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=62, Terminated, Eli Lilly and Company | N=105 --> 62 | Completed --> Terminated
    Enrollment change • Trial termination
    |
    paclitaxel • Cyramza (ramucirumab) • zansecimab (LY3127804)
    2ms
    Faricimab Quarterly Maintenance for Neovascular Age Related Macular Degeneration (clinicaltrials.gov)
    P4, N=40, Recruiting, Hospital Authority, Hong Kong | Not yet recruiting --> Recruiting
    Enrollment open
    4ms
    A prospective study to evaluate the alterations of early macular microcirculation following intravitreal injection of faricimab for macular edema secondary to branch retinal vein occlusion (ChiCTR2500106303)
    P4, N=44, Not yet recruiting, The Second Affiliated Hospital of Chongqing Medical University; The Second Affiliated Hospital of Chongqing Medical University
    New P4 trial
    5ms
    Faricimab Quarterly Maintenance for Neovascular Age Related Macular Degeneration (clinicaltrials.gov)
    P4, N=40, Not yet recruiting, Hospital Authority, Hong Kong | Initiation date: Feb 2025 --> Jul 2025 | Trial primary completion date: Jul 2026 --> Oct 2026
    Trial initiation date • Trial primary completion date
    5ms
    POYANG: A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic Myopia (clinicaltrials.gov)
    P3, N=280, Active, not recruiting, Hoffmann-La Roche | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Lucentis (ranibizumab)
    5ms
    Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor (clinicaltrials.gov)
    P1, N=59, Completed, Dana-Farber Cancer Institute | Active, not recruiting --> Completed | Trial completion date: Aug 2026 --> Dec 2024 | Trial primary completion date: Feb 2026 --> Dec 2024
    Trial completion • Trial completion date • Trial primary completion date
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF V600E • BRAF V600 • BRAF V600K
    |
    Keytruda (pembrolizumab) • trebananib (AMG 386)
    6ms
    FAN: Faricimab for High-frequent Aflibercept Treated Neovascular Age-related Macular Degeneration (clinicaltrials.gov)
    P4, N=70, Completed, Medical University of Graz | Active, not recruiting --> Completed | Trial completion date: Jun 2025 --> Feb 2025 | Trial primary completion date: Mar 2025 --> Sep 2024
    Trial completion • Trial completion date • Trial primary completion date
    6ms
    Identification of OCT-based imaging biomarkers for predicting treatment response of refractory diabetic macular edema to faricimab and dexamethasone implant. A real-world prospective study (ChiCTR2500101034)
    P=N/A, N=80, Not yet recruiting, Chinese University of Hong Kong; Department of Ophthalmology and Visual Sciences (DOVS), The Chinese University of Hong Kong
    New trial • Real-world evidence
    6ms
    SHort Of Pace - Heart Failure (SHOP-HF) (clinicaltrials.gov)
    P=N/A, N=30, Not yet recruiting, Fundación para la Investigación del Hospital Clínico de Valencia
    New trial
    |
    L1-10