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    BIOMARKER:

    ANG elevation

    i
    Other names: ANG, RNA AddSE5, Angiogenin, ribonuclease, RNase A family, 5
    Entrez ID:
    283
    1m
    Inflammation, endothelial injury, and the acute respiratory distress syndrome after out-of-hospital cardiac arrest. (PubMed, Resusc Plus)
    Latent phase analysis demonstrated that patients with low biomarker levels aside from TNF-α and TNFR-1 (Class 2) fared worse than other patients. Future research may benefit from considering other tools to predict and prevent development of ARDS in this population.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • MMP9 (Matrix metallopeptidase 9) • MPO (Myeloperoxidase)
    |
    ANG elevation
    7ms
    Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody. (PubMed, Mol Ther Oncolytics)
    A 28.6% reduction in maximum target lesion diameter was achieved when PRL3-zumab was administered concurrently with hypofractionated radiation. These findings support wider exploration of PRL3 expression in embryonal and mesenchymal tumors and further clinical application of PRL3-zumab in pediatric patients.
    Journal
    |
    TIMP1 (Tissue inhibitor of metalloproteinases 1) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • PTP4A3 (Protein Tyrosine Phosphatase 4A3)
    |
    ANG elevation
    |
    PRL3-Zumab
    11ms
    ROLE OF INTERLEUKIN 6 AND ANGIOPOIETINS 1 AND 2 IN THE EVOLUTION OF PATIENTS DIAGNOSED WITH MULTIPLE MYELOMA (EHA 2023)
    Regarding our findings and observations, we can affirm that: An inverse and statistically significant association were observed between Ang1 and Ang2. The behavior of these angiogenic biomarkers described an increase in Ang2 in those cases where the disease progressed, compared to Ang1 that decreased. After the results described above, we can suggest that obtaining a low Ang1/Ang2 ratio (<6) was correlated with a greater probability of having an unfavorable response to treatment and a torpid evolution of MM.
    Clinical
    |
    IL6 (Interleukin 6)
    |
    ANG elevation