amitriptyline

P4, N=120, Not yet recruiting, Stanford University

P1, N=20, Not yet recruiting, Wright State University

P2, N=100, Recruiting, University of Michigan | Not yet recruiting --> Recruiting

P=N/A, N=80, Recruiting, Nanchong Central Hospital

P3, N=42, Recruiting, St. Joseph's Healthcare Hamilton | Not yet recruiting --> Recruiting

Moreover, when combined with LPA, amitriptyline curtailed Rho activation and the Rho-mediated cellular responses. (4) These results demonstrate that in astroglial cells, amitriptyline exerts a balanced action on LPA-activated receptors by enhancing the neuroprotective ERK1/2-CREB-BDNF signaling and dampening the potentially detrimental Rho-ROCK pathway, and suggest that this unique property may contribute to the antidepressant activity of the drug.

P2, N=100, Not yet recruiting, University of Michigan

Moreover, AMI suppressed the expression of PD-L1 in cells that had been exposed to or had not been exposed to radiation, whereas radiation enhanced its expression. Because AMI exhibited promising anticancer properties including an interesting, previously unknown immunomodulatory effect, it appears that its potential therapeutic should be verified in an in vivo study.

P=N/A, N=40, Recruiting, AdventHealth

P1, N=0, Withdrawn, Vanderbilt University Medical Center | N=100 --> 0 | Enrolling by invitation --> Withdrawn

P4, N=18, Completed, The University of Sydney | Recruiting --> Completed

P4, N=240, Not yet recruiting, Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz