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    DRUG:

    amitriptyline

    Company:
    Generic mfg.
    Drug class:
    Norepinephrine reuptake inhibitor, Serotonin reuptake inhibitor
    Related drugs:
    14d
    MRP-HAND: Multiprofen-CC to Reduce Pain in Hand Arthritis (clinicaltrials.gov)
    P3, N=42, Recruiting, St. Joseph's Healthcare Hamilton | Not yet recruiting --> Recruiting
    Enrollment open
    |
    amitriptyline
    14d
    The Antidepressant Amitriptyline Upregulates ERK1/2 Signaling and Inhibits Rho-Mediated Responses Induced by Lysophosphatidic Acid in Astroglial Cells. (PubMed, Int J Mol Sci)
    Moreover, when combined with LPA, amitriptyline curtailed Rho activation and the Rho-mediated cellular responses. (4) These results demonstrate that in astroglial cells, amitriptyline exerts a balanced action on LPA-activated receptors by enhancing the neuroprotective ERK1/2-CREB-BDNF signaling and dampening the potentially detrimental Rho-ROCK pathway, and suggest that this unique property may contribute to the antidepressant activity of the drug.
    Journal
    |
    MAP2K1 (Mitogen-activated protein kinase kinase 1)
    |
    amitriptyline
    19d
    AIMS-CD: Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease (clinicaltrials.gov)
    P2, N=100, Not yet recruiting, University of Michigan
    New P2 trial
    |
    amitriptyline
    1m
    Two faces of Amitriptyline in an in vitro study on C6 glioma cells: The effects of Amitriptyline and its combination with Temozolomide and radiation. (PubMed, Mol Clin Oncol)
    Moreover, AMI suppressed the expression of PD-L1 in cells that had been exposed to or had not been exposed to radiation, whereas radiation enhanced its expression. Because AMI exhibited promising anticancer properties including an interesting, previously unknown immunomodulatory effect, it appears that its potential therapeutic should be verified in an in vivo study.
    Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    temozolomide • amitriptyline
    1m
    The Treatment of Painful Diabetic Neuropathy With Diet (clinicaltrials.gov)
    P=N/A, N=40, Recruiting, AdventHealth
    New trial
    |
    amitriptyline
    2ms
    RCTVM: Comparison of Amitriptyline to Lifestyle Modification as Intervention for Vestibular Migraine (clinicaltrials.gov)
    P1, N=0, Withdrawn, Vanderbilt University Medical Center | N=100 --> 0 | Enrolling by invitation --> Withdrawn
    Enrollment change • Trial withdrawal
    |
    amitriptyline
    3ms
    AHT: The influence of amitriptyline on human thermoregulation in young healthy adults (ACTRN12623001158651)
    P4, N=18, Completed, The University of Sydney | Recruiting --> Completed
    Trial completion
    |
    amitriptyline
    3ms
    Clinical trial to evaluate the effectiveness and efficiency of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT clinical trial. (2025-522967-13-00)
    P4, N=240, Not yet recruiting, Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz
    New P4 trial
    |
    SLC6A4 (Solute Carrier Family 6 Member 4) • HTR2A (5-Hydroxytryptamine Receptor 2A)
    |
    amitriptyline • imipramine
    4ms
    MACS-2: Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough (clinicaltrials.gov)
    P2, N=25, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Oct 2026 | Trial primary completion date: Dec 2025 --> Oct 2026
    Trial completion date • Trial primary completion date
    |
    amitriptyline
    4ms
    MACS-1: Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough (clinicaltrials.gov)
    P2, N=50, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    amitriptyline
    4ms
    MRP-HAND: Multiprofen-CC to Reduce Pain in Hand Arthritis (clinicaltrials.gov)
    P3, N=42, Not yet recruiting, McMaster University | Initiation date: Aug 2025 --> Jan 2026
    Trial initiation date
    |
    amitriptyline
    5ms
    TPS-Select: An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service (clinicaltrials.gov)
    P3, N=126, Not yet recruiting, University of California, San Francisco
    New P3 trial
    |
    amitriptyline