ALPL (Alkaline Phosphatase)

In this study, we develop β-tricalcium phosphate (β-TCP) granules decorated with selenium (Se)-doped mesoporous silica nanoparticles (SeMIA@TCP), in which nanoparticles are functionalized with imine bonds for acidic pH-responsive detachment and alendronate for strong β-TCP binding...Furthermore, the released nanoparticles enhanced alkaline phosphatase (ALP) expression and mineralization in hMSCs, underscoring their osteogenic potential. Collectively, these results demonstrate the potential of tumor microenvironment-responsive Se-doped MSN-assembled TCP granules as a design platform for bifunctional scaffolds in bone cancer treatment.

P=N/A, N=55, Recruiting, AstraZeneca

© 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland

The addition of TCM to PD‑1/PD‑L1 inhibitors prolongs PFS and OS in patients with stage IIIB-IV NSCLC. A survival prediction model based on routine clinical characteristics demonstrates predictive utility, offering a potential tool to inform clinical decision‑making.

P3, N=124, Active, not recruiting, Alexion Pharmaceuticals, Inc. | Trial completion date: Jul 2028 --> Mar 2028

In addition, a significant decrease in the expression of alkaline phosphatase liver/bone/kidney (p < 0.05, effect size of 0.46 (95% CI: 0.08 to 0.73)) and a significant increase (p < 0.05, effect size was -0.42 (95%CI: -0.72 to 0.01)) in the expression of tumor necrosis factor α were observed in the MRONJ group. These results may contribute to a better understanding of the etiology, pathophysiology, and progression of MRONJ.

ALPL is a key biomarker in THCA, driving tumor progression and poor outcomes through its roles in proliferation, invasion, and immune modulation. These findings support its potential as a diagnostic and prognostic marker.

Knockout cells also displayed altered morphology, suggesting that MPP7 influences osteoblast function via effects on cell polarity and adhesion. Collectively, our findings, together with zebrafish genetic evidence, indicate that MPP7 plays a critical role in osteoblast differentiation and mineralization and may contribute to osteoporosis susceptibility in humans.

The inverse relationship between expression of the genes of leukemic stemness cell markers SNAIL, OCT4, and PLAP and the genes of myeloid differentiation markers C/EBPα, TNAP, and E-cadherin in K562 cells exposed to alpha-tocopherol or G-CSF suggests the activation of the molecular pattern of myeloid differentiation in this setting.

P=N/A, N=1571, Enrolling by invitation, Alexion Pharmaceuticals, Inc. | N=900 --> 1571

P=N/A, N=30, Recruiting, Alexion Pharmaceuticals, Inc. | Trial completion date: Aug 2029 --> Jul 2028 | Trial primary completion date: Aug 2029 --> Jul 2028

P3, N=30, Active, not recruiting, Alexion Pharmaceuticals, Inc. | Recruiting --> Active, not recruiting