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    GENE:

    ALPK2 (Alpha Kinase 2)

    i
    Other names: ALPK2, Alpha Kinase 2, HAK, Heart Alpha-Protein Kinase, Alpha-Protein Kinase 2, Heart Alpha-Kinase
    5ms
    Identifying an immunogenic cell death-related gene signature and HSPA6 infers adverse prognosis in acute myeloid leukemia. (PubMed, J Cancer)
    Notably, HSPA6 emerged as a critical ICDG, with its knockdown in OCI-AML3 cells significantly inhibiting proliferation and inducing apoptosis, suggesting its potential as a therapeutic target. In summary, our research emphasizes the importance of ICD-related genes in predicting the prognosis of AML and initiates the development of a prognostic risk signature that may pave the way for personalized treatment strategies while highlighting the need for further validation and exploration of HSPA6 in AML.
    Journal • Gene Signature
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    CD8 (cluster of differentiation 8) • GZMB (Granzyme B) • ALPK2 (Alpha Kinase 2) • FCGR2B (Fc Fragment Of IgG Receptor IIb) • HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6)
    8ms
    Proteomic and transcriptomic profiling in exosomes derived from HPV-positive head and neck cancer. (PubMed, Biochem Biophys Res Commun)
    Importantly, receiver operating characteristic (ROC) analysis indicated that the combination of HPV-related proteins (eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), NF-κB p65 (RELA)) and miRNA (miR-130b) as a panel can discriminate the HPV-positive HNC patients from controls (Area under the curve (AUC) = 0.993, Sensitivity 95 % and Specificity 100 %) as well as between HPV-negative and -positive HNC patients (AUC = 0.781, Sensitivity 81 % and Specificity 67 %) based on the TCGA-HNC dataset. In summary, our findings may offer new insights into the key molecular cargo loading into HPV-enriched exosomes, which could potentially underpin the future design of novel diagnostic and prognostic approaches for predicting HPV-positive HNC.
    Journal
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    ALPK2 (Alpha Kinase 2) • RELA (RELA Proto-Oncogene)
    11ms
    Hydroa vacciniforme lymphoproliferative disorder, a clinicopathologic and genetic analysis. (PubMed, Hum Pathol)
    Most patients were treated with immunomodulating therapy, two received methotrexate, three received multiagent chemotherapy and one underwent hematopoietic stem cell transplant...Our results showed that patients with persistent/progressive systemic HV-LPD have a poor prognosis and do not respond well to chemotherapy. The mutation spectrum bore some resemblance to extranodal NK/T lymphomas but also had notable differences.
    Journal
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    TP53 (Tumor protein P53) • CD20 (Membrane Spanning 4-Domains A1) • CD8 (cluster of differentiation 8) • TNFRSF8 (TNF Receptor Superfamily Member 8) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • CREBBP (CREB binding protein) • BCOR (BCL6 Corepressor) • KDM6A (Lysine Demethylase 6A) • NCAM1 (Neural cell adhesion molecule 1) • IRF8 (Interferon Regulatory Factor 8) • RHOA (Ras homolog family member A) • STAT5B (Signal Transducer And Activator Of Transcription 5B) • NCOR1 (Nuclear Receptor Corepressor 1) • NCOR2 (Nuclear Receptor Corepressor 2) • ZFHX3 (Zinc Finger Homeobox 3) • GZMB (Granzyme B) • IRF4 (Interferon regulatory factor 4) • PRDM1 (PR/SET Domain 1) • ALPK2 (Alpha Kinase 2) • BCORL1 (BCL6 Corepressor Like 1) • DDX3X (DEAD-Box Helicase 3 X-Linked)
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    TP53 mutation • CD20 positive • TET2 mutation
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    methotrexate
    1year
    A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease. (PubMed, Actas Esp Psiquiatr)
    A six-gene diagnosis model was constructed and verified to exhibit robust diagnostic ability in AD.
    Journal • Gene Signature
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    NOTCH1 (Notch 1) • ALPK2 (Alpha Kinase 2) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • SOD1 (Superoxide Dismutase 1)
    over1year
    EIF2AK2 protein targeted activation of AIM2-mediated PANoptosis promotes sepsis-induced acute kidney injury. (PubMed, Ren Fail)
    Notably, EIF2AK2 induced PANoptosis through upregulating AIM2 in HK-2 cells stimulated by LPS. Our results revealed the important role of EIF2AK2-induced AIM2 upregulation in the activation of PANoptosis during septic AKI.
    Journal
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    AIM2 (Absent In Melanoma 2) • ALPK2 (Alpha Kinase 2)
    almost2years
    Discovery of Novel Potential Prognostic Markers and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced-Stage Wilms Tumor. (PubMed, Cancers (Basel))
    Based on the mutation profiles of the resistant WT samples, we propose potential therapeutic strategies involving platinum-based agents, PARP inhibitors, and antibiotic/antineoplastic agents. Our findings provide insights into the genetic landscape of WT and offer potential avenues for targeted treatment, particularly for patients with chemotherapy resistance.
    Journal • PARP Biomarker • Metastases
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    ALPK2 (Alpha Kinase 2) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit)
    over2years
    Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer. (PubMed, Chin Med J (Engl))
    This study describes screening for DEGs in HGSOC primary tumors and matched metastasis tumors using integrated bioinformatics analyses. We identified six hub genes that were correlated with the progression of HGSOC, particularly FAP and SFRP2, which might provide effective targets to predict prognosis and provide novel insights into individual therapeutic strategies for HGSOC.
    Journal
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    ALPK2 (Alpha Kinase 2) • FABP4 (Fatty Acid Binding Protein 4)
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    FAP expression
    almost3years
    IFN-beta and EIF2AK2 are potential biomarkers for interstitial lung disease in anti-MDA5 positive dermatomyositis. (PubMed, Rheumatology (Oxford))
    IFN-beta and EIF2AK2 contributed to the pathogenesis of MDA5+ DM-ILD, which could be used as potential therapeutic targets.
    Journal
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    ALPK2 (Alpha Kinase 2) • IFIH1 (Interferon Induced With Helicase C Domain 1)
    almost3years
    Apatinib combined with camrelizumab in advanced acral melanoma patients: An open-label, single-arm phase 2 trial. (PubMed, Eur J Cancer)
    Apatinib combined with camrelizumab showed manageable safety profile and reasonable anti-tumour activity in advanced acral melanoma patients as first-line therapy.
    P2 data • Clinical Trial,Phase II • Journal • PD(L)-1 Biomarker • Metastases
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    MUC16 (Mucin 16, Cell Surface Associated) • ALPK2 (Alpha Kinase 2) • SCUBE1 (Signal Peptide, CUB Domain And EGF Like Domain Containing 1) • VPS13D (Vacuolar Protein Sorting 13 Homolog D)
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    MUC16 mutation • TTN mutation
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    AiRuiKa (camrelizumab) • AiTan (rivoceranib)
    almost3years
    Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer. (PubMed, Geroscience)
    All data including HR and p values as well as the used cutoff values for all genes for both PFS and OS are provided to enable the ranking of future biomarker candidates across all genes. Our results help to prioritize genes and to neglect those which are most likely to fail in studies aiming to establish new clinically useful biomarkers and therapeutic targets in serous ovarian cancer.
    Journal
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    ALPK2 (Alpha Kinase 2) • SHKBP1 (SH3KBP1 Binding Protein 1)