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    DRUG:

    alphataxin

    i
    Other names: alphataxin, Alpha-101
    Associations

    News

    Trials
    Company:
    Alpha-1 Biologics
    Drug class:
    CD4 T cell stimulant
    Related drugs:
    Associations

    News

    Trials
    almost3years
    Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4 T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis. (PubMed, Front Oncol)
    Lung metastasis was present in monotherapy, but significantly reduced in combination-treated mice. Orally available Alphataxin, the first and only drug developed to increase CD4 T cells, in combination with anti-PD-1, is a powerful therapeutic method that provides long-term remission in renal cell carcinoma and potentially other T cell-responsive cancers by increasing the number of CD4 tumor-infiltrating T cells.
    Preclinical • Journal • Combination therapy
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    CD8 (cluster of differentiation 8) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule)
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    alphataxin