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    GENE:

    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)

    i
    Other names: ALOX12, Arachidonate 12-Lipoxygenase, 12S Type , 12S-LOX, Polyunsaturated Fatty Acid Lipoxygenase ALOX12, Arachidonate 12-Lipoxygenase, 12S-Type, Arachidonate (12S)-Lipoxygenase, Arachidonate (15S)-Lipoxygenase, Platelet-Type Lipoxygenase 12, Lipoxin Synthase 12-LO, 12S-Lipoxygenase, Platelet 12-LOX, LOG12, Arachidonate 15-Lipoxygenase,15S-Type, Platelet-Type 12-Lipoxygenase, Arachidonate 12-Lipoxygenase, Linoleate (13S)-Lipoxygenase, Linoleate 13S-Lipoxygenase, 12-LOX, 12LO
    Associations

    News

    Trials
    5ms
    Piperine targets SOAT1 to inhibit the progression of esophageal squamous cell carcinoma via ferroptosis. (PubMed, Phytomedicine)
    This study is the first to demonstrate that piperine targets SOAT1 to enhance ferroptosis by inhibiting the PI3K-AKT axis and upregulating the expression of KLF4/ALOX12B. This study strongly emphasizes the potential of piperine as a promising clinical therapeutic candidate for ESCC.
    Journal
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    KLF4 (Kruppel-like factor 4) • ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) • ALOX12B (Arachidonate 12-Lipoxygenase)
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    cisplatin
    8ms
    Switch-like gene expression modulates disease risk. (PubMed, Nat Commun)
    We propose that switched-off driver genes in basal and parabasal epithelia suppress cell proliferation, leading to epithelial thinning and vaginal atrophy. Our findings underscore the implications of switch-like genes for diagnostic and personalized therapeutic applications.
    Journal
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    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
    10ms
    Baicalin Inhibits Lung Cancer Cell Proliferation and Migration via ALOX12-Mediated Ferroptosis. (PubMed, Anticancer Agents Med Chem)
    Baicalin significantly upregulated ALOX12 expression, promoted ferroptosis, and inhibited the proliferation and migration of A549 lung cancer cells. This finding provides evidence for the potential use of baicalin as a therapeutic agent for lung cancer and highlights the importance of ALOX12 in lung cancer treatment strategies.
    Journal
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    GPX4 (Glutathione Peroxidase 4) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
    11ms
    Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer. (PubMed, Hereditas)
    Six genes, namely ALOX12, EZH2, CA9, CDCA3, CDC25A, and HSPB1, were identified as m6A-regulated ferroptosis biomarkers in CC. These findings offer valuable insights into disease pathogenesis and hold promise for advancing CC treatment and prognosis.
    Journal
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    EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • CA9 (Carbonic anhydrase 9) • CDCA3 (Cell Division Cycle Associated 3) • HSPB1 (Heat shock 27kDa protein 1) • ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    1year
    Decoding the Ferroptosis-Related Gene Signatures and Immune Infiltration Patterns in Ovarian Cancer: Bioinformatic Prediction Integrated with Experimental Validation. (PubMed, J Inflamm Res)
    The ovarian cancer cell invasion and migration were significantly inhibited after induction of ferroptosis. We decoded the ferroptosis-related gene signatures and immune infiltration patterns that can be used to predict the prognosis of ovarian cancer patients.
    Journal • Gene Signature
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    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
    over1year
    Palmitic acid inhibits macrophage-mediated chemotherapy resistance in multiple myeloma via ALOX12 signaling. (PubMed, Int Immunopharmacol)
    Moreover, treatment with AA but not 12-HETE partially abrogated the inhibitory effect of palmitic acid on MΦ-mediated MM cell survival in response to bortezomib or melphalan. Overall, we identified palmitic acid as a factor that inhibits MΦ-mediated resistance to bortezomib and melphalan in MM, which may have clinical significance.
    Journal
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    FAS (Fas cell surface death receptor) • FASN (Fatty acid synthase) • ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
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    bortezomib • melphalan
    over1year
    Switch-like Gene Expression Modulates Disease Susceptibility. (PubMed, Res Sq)
    We propose a model wherein the switching off of driver genes in basal and parabasal epithelium suppresses cell proliferation therein, leading to epithelial thinning and, therefore, vaginal atrophy. Our findings underscore the significant biomedical implications of switch-like gene expression and lay the groundwork for potential diagnostic and therapeutic applications.
    Journal
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    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
    over1year
    Switch-like Gene Expression Modulates Disease Susceptibility. (PubMed, bioRxiv)
    We propose a model wherein the switching off of driver genes in basal and parabasal epithelium suppresses cell proliferation therein, leading to epithelial thinning and, therefore, vaginal atrophy. Our findings underscore the significant biomedical implications of switch-like gene expression and lay the groundwork for potential diagnostic and therapeutic applications.
    Journal
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    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
    over1year
    Induction of ferroptosis by brucine suppresses gastric cancer progression through the p53-mediated SLCA711/ALOX12 axis. (PubMed, Heliyon)
    In summary, we demonstrated that brucine regulates the p53/SLCA711/ALOX12 axis to cause ferroptosis in GC cells. The results of this study lend support to the idea of treating GC with brucine.
    Journal
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    SLC7A11 (Solute Carrier Family 7 Member 11) • ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
    over1year
    Prognostic value of genomic mutation signature associated with immune microenvironment in southern Chinese patients with esophageal squamous cell carcinoma. (PubMed, Cancer Immunol Immunother)
    Furthermore, the results of immunofluorescence double staining showed that patients with high risk scores had a significantly higher level of M2 macrophage than those with low risk scores (p < 0.05). In conclusion, our study provides insights into the genomic landscape of ESCC and highlights the prognostic value of a genomic mutation signature associated with the immune microenvironment in southern Chinese patients with ESCC.
    Journal • IO biomarker
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    PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • IFNG (Interferon, gamma) • KMT2D (Lysine Methyltransferase 2D) • LRP1B (LDL Receptor Related Protein 1B) • KMT2C (Lysine Methyltransferase 2C) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • FAT1 (FAT atypical cadherin 1) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • ITGB2 (Integrin Subunit Beta 2) • LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) • TNFSF4 (TNF Superfamily Member 4) • ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) • ALOX12B (Arachidonate 12-Lipoxygenase) • BTN3A1 (Butyrophilin Subfamily 3 Member A1) • SLX4 (SLX4 Structure-Specific Endonuclease Subunit)
    almost2years
    Enhanced ALOX12 Gene Expression Predicts Therapeutic Susceptibility to 5-Azacytidine in Patients with Myelodysplastic Syndromes. (PubMed, Int J Mol Sci)
    In addition, we further found that (1) the ALOX12 gene was hypermethylated in patients with MDS compared to healthy controls; (2) MDS classes with excess blasts showed a relatively lower expression of ALOX12 than other classes; (3) a lower expression of ALOX12 correlated with higher bone marrow blasts and a shorter survival in patients with MDS; and (4) an increased ALOX12 expression after AZA treatment was associated with a favorable response to AZA treatment. Taking these factors together, an enhanced expression of the ALOX12 gene may predict favorable therapeutic responses to AZA therapy in MDS.
    Journal
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    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type)
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    azacitidine
    2years
    Solanine induces ferroptosis in colorectal cancer cells through ALOX12B/ADCY4 molecular axis. (PubMed, J Pharm Pharmacol)
    Our data demonstrated the ferroptosis-inducing effect of solanine in CRC cells, and revealed ALOX12B/ADCY4 molecular axis as the ferroptosis mediator of solanine. Solanine may synergize with existing ferroptosis inducer as an anticancer strategy in CRC, which warrants further validation in animal experiments.
    Journal
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    ALOX12 (Arachidonate 12-Lipoxygenase, 12S Type) • ALOX12B (Arachidonate 12-Lipoxygenase)