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DRUG:

AlloStim (bioengineered allogeneic immune cells)

i
Other names: bioengineered allogeneic immune cells, T-Stim cells
Associations
Company:
Immunovative
Drug class:
Immunostimulant
Related drugs:
Associations
2ms
COMUNITY: Combined AlloStim+Anti-PD-L1 in 4L MSS Metastatic Colorectal Cancer (clinicaltrials.gov)
P2, N=50, Not yet recruiting, Mirror Biologics, Inc. | Trial completion date: Mar 2026 --> Nov 2025
Trial completion date
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Bavencio (avelumab) • AlloStim (bioengineered allogeneic immune cells)
2ms
COMUNITY: Combined AlloStim+Anti-PD-L1 in MSS Metastatic Colorectal Cancer (clinicaltrials.gov)
P2, N=50, Not yet recruiting, Mirror Biologics, Inc. | Trial primary completion date: Dec 2025 --> Mar 2026
Trial primary completion date • Metastases
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Bavencio (avelumab) • AlloStim (bioengineered allogeneic immune cells)
3ms
New P2 trial • Metastases
|
Bavencio (avelumab) • AlloStim (bioengineered allogeneic immune cells)
9ms
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2, N=24, Recruiting, Immunovative Therapies, Ltd. | Phase classification: P2b --> P2 | Trial completion date: Apr 2024 --> Apr 2025 | Trial primary completion date: Nov 2023 --> Nov 2024
Phase classification • Trial completion date • Trial primary completion date • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS wild-type • RAS wild-type
|
AlloStim (bioengineered allogeneic immune cells)
9ms
ALIVE: Immunotherapy for Advanced Liver Cancer (clinicaltrials.gov)
P2/3, N=150, Recruiting, Immunovative Therapies, Ltd. | Not yet recruiting --> Recruiting
Enrollment open • Metastases
|
sorafenib • 5-fluorouracil • Lenvima (lenvatinib) • leucovorin calcium • AlloStim (bioengineered allogeneic immune cells)
over1year
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Recruiting, Immunovative Therapies, Ltd. | Trial completion date: Sep 2023 --> Apr 2024 | Trial primary completion date: Mar 2023 --> Nov 2023
Trial completion date • Trial primary completion date • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS wild-type • RAS wild-type
|
AlloStim (bioengineered allogeneic immune cells)
2years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Recruiting, Immunovative Therapies, Ltd. | Trial completion date: Feb 2023 --> Sep 2023 | Trial primary completion date: Sep 2022 --> Mar 2023
Trial completion date • Trial primary completion date
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS wild-type • RAS wild-type
|
AlloStim (bioengineered allogeneic immune cells)
over3years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Recruiting, Immunovative Therapies, Ltd. | Not yet recruiting --> Recruiting
Clinical • Enrollment open
|
KRAS (KRAS proto-oncogene GTPase)
|
AlloStim (bioengineered allogeneic immune cells)
over3years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Not yet recruiting, Immunovative Therapies, Ltd. | Trial primary completion date: Sep 2022 --> Dec 2022
Clinical • Trial primary completion date
|
KRAS (KRAS proto-oncogene GTPase)
|
AlloStim (bioengineered allogeneic immune cells)
almost4years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Not yet recruiting, Immunovative Therapies, Ltd. | Trial completion date: Dec 2021 --> Mar 2023 | Trial primary completion date: Oct 2021 --> Sep 2022
Clinical • Trial completion date • Trial primary completion date
|
KRAS (KRAS proto-oncogene GTPase)
|
AlloStim (bioengineered allogeneic immune cells)
4years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Not yet recruiting, Immunovative Therapies, Ltd. | Initiation date: Oct 2020 --> Jan 2021
Clinical • Trial initiation date
|
KRAS (KRAS proto-oncogene GTPase)
|
AlloStim (bioengineered allogeneic immune cells)
over4years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Not yet recruiting, Immunovative Therapies, Ltd. | Initiation date: Jul 2020 --> Oct 2020 | Trial primary completion date: Jul 2021 --> Oct 2021
Clinical • Trial initiation date • Trial primary completion date
|
KRAS (KRAS proto-oncogene GTPase)
|
AlloStim (bioengineered allogeneic immune cells)
over4years
STIMVAX: Immunotherapy for Third Line Metastatic Colorectal Cancer (clinicaltrials.gov)
P2b, N=24, Not yet recruiting, Immunovative Therapies, Ltd.
Clinical • New P2b trial
|
KRAS (KRAS proto-oncogene GTPase)
|
AlloStim (bioengineered allogeneic immune cells)
almost5years
AlloStim® In-Situ Vaccine in Pre-Treated Metastatic Colorectal Cancer (clinicaltrials.gov)
P2/3, N=0, Withdrawn, Immunovative Therapies, Ltd. | N=450 --> 0 | Not yet recruiting --> Withdrawn
Clinical • Enrollment change • Trial withdrawal
|
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
KRAS mutation • BRAF mutation
|
Erbitux (cetuximab) • AlloStim (bioengineered allogeneic immune cells)
almost5years
AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer (clinicaltrials.gov)
P2a, N=12, Completed, Immunovative Therapies, Ltd. | Recruiting --> Completed | Phase classification: P2 --> P2a | N=18 --> 12
Clinical • Trial completion • Phase classification • Enrollment change • Combination therapy
|
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
AlloStim (bioengineered allogeneic immune cells)