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DRUG:

ALLO-316

i
Other names: ALLO-316, anti-CD70 AlloCAR T, ALLO316, ALLO 316
Company:
Allogene Therap, Cellectis
Drug class:
CD70-targeted CAR-T immunotherapy
1year
TRAVERSE: Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma (clinicaltrials.gov)
P1, N=120, Recruiting, Allogene Therapeutics | Trial primary completion date: Dec 2022 --> Aug 2025
Trial primary completion date • Metastases
|
cyclophosphamide • fludarabine IV • ALLO-316 • ALLO-647
4years
[VIRTUAL] Investigation of ALLO-316: A Fratricide-Resistant Allogeneic CAR T Targeting CD70 As a Potential Therapy for the Treatment of AML (ASH 2020)
Approval of two CD19-targeting autologous CAR Ts, Kymriah® and Yescarta®, has been followed with promising results from BCMA autologous CAR T clinical trials, showing that activity can extend to other targets...Cellectis’ TALEN® gene-editing was used to inactivate the TRAC and CD52 loci with the intent to minimize the risk of graft-versus-host disease and to confer resistance to ALLO-647, an anti-CD52 antibody that can be used as part of the conditioning regimen to deplete host alloreactive immune cells potentially leading to increased persistence and efficacy of the infused allogeneic cells...No detectable CD70 was observed by flow cytometry on purified CD34+ cells from 14 healthy donors. Taken together, our results support clinical development of CD70 AlloCAR T therapy for the treatment of AML.
IO biomarker
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CD19 (CD19 Molecule) • CD70 (CD70 Molecule) • CD34 (CD34 molecule) • CD27 (CD27 Molecule)
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CD70 expression
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Yescarta (axicabtagene ciloleucel) • Kymriah (tisagenlecleucel-T) • ALLO-316 • ALLO-647