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    BIOMARKER:

    ALK1 rearrangement

    i
    Other names: ALK1, Activin A Receptor Like Type 1, Serine/Threonine-Protein Kinase Receptor R3, Activin A Receptor Type II-Like 1, TGF-B Superfamily Receptor Type I, Activin Receptor-Like Kinase 1, Activin A Receptor Type IL, ACVRLK1, TSR-I, SKR3, Activin A Receptor, Type II-Like Kinase 1, HHT2
    Entrez ID:
    94
    Related biomarkers:
    Expression
    over2years
    Primary gastrointestinal anaplastic large cell lymphoma: A critical reappraisal with a systematic review of the world literature. (PubMed, J Cancer Res Ther)
    ALCL primarily involving gastrointestinal (GI) tract is rare. In this manuscript, we describe a case of primary esophageal ALK1 positive-ALCL (null phenotype) in a young female, who presented with fleshy mucosal lesion in the lower third of the esophagus and present a systematic review of 35 cases of GI-ALCL reported in the English literature over the past 28 years (1990-2018) with regard to the clinicopathological characteristics, therapy, and outcome.
    Review • Journal
    |
    ALK (Anaplastic lymphoma kinase) • ALK1 (Activin A Receptor Like Type 1)
    |
    ALK rearrangement • ALK1 rearrangement
    3years
    Plasma biopsy by Tag-sequencing: an acceptable alternative to tumor tissue profiling in non-small-cell lung cancer. (PubMed, Pol J Pathol)
    Almost perfect agreement was reached for detecting actionable EGFR mutations and ALK1 rearrangement (κ of 0.89 and κ of 1, respectively), which was confirmed by single-gene testing. Substantial agreement between the assays makes Tag-sequencing a viable option for identifying multibiomarkers from the plasma of advanced NSCLC patients in special circumstances where tissue has depleted/tumor is inaccessible/high risk of biopsy due to existing comorbidities.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • ALK1 (Activin A Receptor Like Type 1)
    |
    KRAS mutation • EGFR mutation • ALK rearrangement • ALK1 rearrangement • EGFR mutation + KRAS mutation
    almost4years
    ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male. (PubMed, Turk Patoloji Derg)
    Hence we recommend performing ALK gene rearrangement analysis in all cases of sarcomatoid lung carcinomas. The report discusses the diagnostic approach and provides insight into the molecular pathogenesis of this exceedingly rare malignancy.
    Journal
    |
    ALK (Anaplastic lymphoma kinase) • ALK1 (Activin A Receptor Like Type 1)
    |
    ALK rearrangement • ALK1 rearrangement