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    BIOMARKER:

    ALDH2 underexpression

    i
    Other names: ALDH2, Aldehyde Dehydrogenase 2 Family Member, Aldehyde Dehydrogenase 2 Family (Mitochondrial), Aldehyde Dehydrogenase, Mitochondrial, ALDH Class 2, ALDH-E2, ALDHI, ALDM, Nucleus-Encoded Mitochondrial Aldehyde Dehydrogenase 2, Epididymis Secretory Sperm Binding Protein, Acetaldehyde Dehydrogenase 2, Liver Mitochondrial ALDH
    Entrez ID:
    217
    Related biomarkers:
    Expression
    5ms
    A Single nucleotide polymorphism in the ALDH2 gene modifies the risk of esophageal squamous cell carcinoma in BRCA2 p.K3326* carriers. (PubMed, PLoS One)
    Among a total of 464 individuals with TT genotype of the ALDH2 rs10744777 polymorphism, which is associated with lower ALDH2 expression, we found 9 of 164 cases versus 3 of 300 controls who carried the BRCA2 p.K3326* variant (OR = 5.66, 95% CI = 1.22-26.2, P = 0.018). This finding supports our hypothesis that the ALDH2-rs10744777 TT genotype may be a significant risk modifier of ESCC in individuals with a BRCA2 p.K3326* mutation.
    Journal • BRCA Biomarker
    |
    BRCA2 (Breast cancer 2, early onset) • ALDH2 (Aldehyde Dehydrogenase 2 Family Member)
    |
    BRCA2 mutation • ALDH2 underexpression
    over1year
    Identifying the Therapeutic and Prognostic Role of the CD8+ T Cell-Related Gene ALDH2 in Head and Neck Squamous Cell Carcinoma. (PubMed, Cancer Inform)
    In addition, we showed the relationship between ALDH2 expression and chemotherapeutic drug sensitivity. In conclusion, this study identified ALDH2 as a prognostic marker, associated with CD8+ T cell infiltration in HNSC.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • ALDH2 (Aldehyde Dehydrogenase 2 Family Member)
    |
    LDH-L • ALDH2 underexpression • CD8-H