P2, N=15, Terminated, SonALAsense, Inc. | N=40 --> 15 | Trial completion date: Aug 2025 --> Jul 2024 | Active, not recruiting --> Terminated; The study is terminated due to lack of funding but not due to safety concerns.
P1/2, N=8, Terminated, SonALAsense, Inc. | Trial completion date: Nov 2026 --> Jul 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Apr 2026 --> Jun 2024; Study is terminated due to funding challenges and not due to safety concerns.
4 months ago
Trial completion date • Trial termination • Trial primary completion date • Combination therapy
Six hours prior to SDT, adult patients with recurrent GBM are administered Sonala-001 (10mg/kg), an IV formulation of 5-ALA...This first-in-human experience with a new therapeutic modality for recurrent glioblastoma patients demonstrates that 5-ALA SDT is safe at 200J. Sonodynamic therapy leads to targeted oxidative stress and tumor cell death in human glioblastoma tissue.