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    BIOMARKER:

    AKT3 E17K

    i
    Other names: AKT3, PKBG, PRKBG, RAC-gamma, V-akt murine thymoma viral oncogene homolog 3
    Entrez ID:
    10000
    Related biomarkers:
    Expression
    Mutation
    over3years
    Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients. (PubMed, Cancer Manag Res)
    Patients in the GDPH cohort had lower rates of AKT and AKT3 mutation and higher AKT1 mutation rate than those in the TCGA cohort, while harboring missense mutations detected predominantly as E17K mutation in AKT1. In GDPH cohort, there were correlations between AKT mutation and the clinicopathological characteristics of patients.
    Clinical • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • AKT1 (V-akt murine thymoma viral oncogene homolog 1)
    |
    HER-2 expression • AKT1 mutation • ER overexpression • AKT3 E17K • AKT3 mutation
    over4years
    AKT1E17K activates focal adhesion kinase and promotes melanoma brain metastasis. (PubMed, Mol Cancer Res)
    These data suggest that the different AKT paralogs have distinct roles in melanoma brain metastasis and that AKT and FAK may be promising therapeutic targets. Implications: This study suggests that AKT1E17K promotes melanoma brain metastasis through activation of focal adhesion kinase and provides a rationale for the therapeutic targeting of AKT and/or FAK to reduce melanoma metastasis.
    Journal
    |
    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT1 mutation • AKT1 Q79K • AKT3 E17K