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    BIOMARKER:

    AKT1 Q79K

    i
    Other names: AKT1, AKT, PKB, PRKBA, RAC, V-akt murine thymoma viral oncogene homolog 1
    Entrez ID:
    207
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    over3years
    [VIRTUAL] AKT1 in Asia: A landscape analysis of 11,813 Chinese tumor samples. (ASCO 2021)
    Higher frequencies of AKT1 mutation were observed in several common cancers, including cervical, breast, osteosarcoma, brain, head and neck and colorectal in our study . AKT1 E17K was more commonly found in breast, brain and cervical cancer . Given the fact that III/IV patients are more common in AKT1 mutated group, it coincides with AKT inhibitors therapeutic prospects in a variety of advanced malignant tumors .
    MSi-H Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • MSI (Microsatellite instability) • AKT1 (V-akt murine thymoma viral oncogene homolog 1)
    |
    MSI-H/dMMR • AKT1 E17K • AKT1 mutation • AKT1 Q79K
    over4years
    AKT1E17K activates focal adhesion kinase and promotes melanoma brain metastasis. (PubMed, Mol Cancer Res)
    These data suggest that the different AKT paralogs have distinct roles in melanoma brain metastasis and that AKT and FAK may be promising therapeutic targets. Implications: This study suggests that AKT1E17K promotes melanoma brain metastasis through activation of focal adhesion kinase and provides a rationale for the therapeutic targeting of AKT and/or FAK to reduce melanoma metastasis.
    Journal
    |
    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • AKT3 (V-akt murine thymoma viral oncogene homolog 3)
    |
    AKT1 mutation • AKT1 Q79K • AKT3 E17K