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    GENE:

    AKAP12 (A-Kinase Anchoring Protein 12)

    i
    Other names: AKAP12, A-Kinase Anchoring Protein 12, AKAP250, SSeCKS, Src-Suppressed C Kinase Substrate, A Kinase (PRKA) Anchor Protein 12, A-Kinase Anchor Protein 12, AKAP 250, Gravin, A Kinase (PRKA) Anchor Protein (Gravin) 12, Myasthenia Gravis Autoantigen Gravin, A-Kinase Anchor Protein, 250kDa, A-Kinase Anchor Protein 250 KDa, Kinase Scaffold Protein Gravin, Myasthenia Gravis Autoantigen, AKAP-12
    Associations

    News

    Trials
    1m
    Cross-Regional Transcriptome Data Reveal Transcriptional Abnormalities Associated with Lung Adenocarcinoma. (PubMed, Rep Biochem Mol Biol)
    Our findings suggest that the expression levels of serglycin, ILK, ESD, and PLPD1 may play a significant role in the development of LAC. This information can be valuable for identifying potential treatment targets for lung cancer.
    Journal
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    CD123 (Interleukin 3 Receptor Subunit Alpha) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • KRT19 (Keratin 19) • AQP1 (Aquaporin 1) • BST1 (Bone Marrow Stromal Cell Antigen 1) • COL3A1 (Collagen Type III Alpha 1 Chain) • SMAD7 (SMAD Family Member 7) • TAGLN (Transgelin) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • AKAP12 (A-Kinase Anchoring Protein 12) • RGS2 (Regulator Of G Protein Signaling 2) • NCOA1 (Nuclear Receptor Coactivator 1)
    3ms
    Construction and validation of risk models of prognostic genes associated with parthanatos in papillary thyroid carcinoma based on bioinformatics. (PubMed, Discov Oncol)
    This study comprehensively mapped PRGs in PTC, established a validated risk model, and provided insights into immune-microenvironment interactions and therapeutic targets, advancing precision oncology for PTC.
    Journal
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    NCAM1 (Neural cell adhesion molecule 1) • CLU (Clusterin) • AKAP12 (A-Kinase Anchoring Protein 12)
    3ms
    Development and validation of a prognostic prediction model for gastric cancer based on lipophagy-related genes. (PubMed, Transl Cancer Res)
    A nomogram was established by integrating each patient's risk score and clinical features (age, gender, and tumor stage). This model exhibits preliminary prognostic discrimination ability in both the training set and the validation set; however, its predictive accuracy is limited and requires further optimization.
    Journal
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    PDK4 (Pyruvate Dehydrogenase Kinase 4) • BST1 (Bone Marrow Stromal Cell Antigen 1) • AKAP12 (A-Kinase Anchoring Protein 12)
    7ms
    Development and validation of a hypoxia-immune-based microenvironment gene signature for predicting survival in non-small cell lung cancer. (PubMed, Discov Oncol)
    The hypoxia-immune microenvironment signature serves as a robust prognostic classifier for NSCLC, providing a quantitative framework for personalized risk stratification and clinical decision support.
    Journal • Gene Signature
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    CXCL13 (Chemokine (C-X-C motif) ligand 13) • CD79A (CD79a Molecule) • SERPINE1 (Serpin Family E Member 1) • AKAP12 (A-Kinase Anchoring Protein 12)
    7ms
    SALL1 functions as a tumor suppressor in hepatocellular carcinoma cells. (PubMed, Biochem Biophys Res Commun)
    Furthermore, stable expression of SALL1 in HCC cells induced the expression of certain liver-specific markers, indicating that SALL1 promotes redifferentiation of HCC cells. These findings suggest that SALL1 may function as a tumor suppressor in HCC and contribute to the development of HCC therapies.
    Journal
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    MIR192 (MicroRNA 192) • AKAP12 (A-Kinase Anchoring Protein 12) • HNF1A (HNF1 Homeobox A) • IGFBP1 (Insulin Like Growth Factor Binding Protein 1) • MIR194 (MicroRNA 194)
    8ms
    Stemness-driven clusters in ovarian cancer: immune characteristics and prognostic implications. (PubMed, Front Oncol)
    Knockdown of AKAP12 reduced tumor sphere formation, impaired cell migration, and enhanced cisplatin sensitivity...This study establishes a novel stemness-related gene signature for prognosis prediction and therapeutic stratification in OC. AKAP12 was identified as a potential biomarker and therapeutic target, offering new avenues for precision treatment in stemness-driven OC.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • TNFSF4 (TNF Superfamily Member 4) • AKAP12 (A-Kinase Anchoring Protein 12)
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    cisplatin
    10ms
    Development and validation of a 16-gene T-cell- related prognostic model in non-small cell lung cancer. (PubMed, Front Immunol)
    High-risk patients responded better to AZD5991-1720, an MCL1 inhibitor, while low-risk patients showed improved responses to IGF1R-3801-1738, an IGF1R inhibitor, suggesting that risk stratification may help optimize treatment selection based on tumor-specific vulnerabilities...However, prospective validation is needed to confirm its clinical applicability. Potential limitations such as sample size and generalizability should be considered.
    Journal
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    LDHA (Lactate dehydrogenase A) • CD69 (CD69 Molecule) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • BAIAP2 (BAR/IMD Domain Containing Adaptor Protein 2) • LATS2 (Large Tumor Suppressor Kinase 2) • MAPK4 (Mitogen-Activated Protein Kinase 4) • AKAP12 (A-Kinase Anchoring Protein 12) • CKAP4 (Cytoskeleton Associated Protein 4) • HOXC10 (Homeobox C10) • DSG2 (Desmoglein 2)
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    AZD5991
    11ms
    AKAP12, mediated by transcription factor 21, inhibits cell proliferation, metastasis, and glycolysis in lung squamous cell carcinoma. (PubMed, Open Life Sci)
    In vivo experiments showed that AKAP12 upregulation reduced LUSC tumorigenesis, and TCF21 knockdown reversed this effect. In conclusion, AKAP12 might be a tumor suppressor in LUSC, which was mediated by TCF21 and could inhibit cell growth, metastasis, and glycolysis to restrain LUSC malignant progression.
    Journal
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    AKAP12 (A-Kinase Anchoring Protein 12)
    1year
    A-kinase anchor protein 12 promotes oligodendrogenesis and cognitive recovery in carbon monoxide therapy for traumatic brain injury. (PubMed, J Cereb Blood Flow Metab)
    These findings highlight the importance of CO-induced AKAP12 upregulation, particularly in pericytes, in supporting oligodendrogenesis and cognitive recovery after TBI. Understanding these mechanisms holds promise for the development of targeted therapies to address TBI-associated impairments.
    Journal
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    AKAP12 (A-Kinase Anchoring Protein 12)
    1year
    Transcriptome sequencing-based study on the mechanism of action of Jintiange capsules in regulating synovial mesenchymal stem cells exosomal miRNA and articular chondrocytes mRNA for the treatment of osteoarthritis. (PubMed, J Tradit Chin Med)
    JTGs can improve the degeneration of joint cartilage and achieve the purpose of cartilage protection, which can be used for the treatment of OA. SMSCs-related miRNA expression profiles were significantly altered after the intervention with JTGs containing serum. The 9 co-differentially expressed genes may be the key targets for the efficacy of JTGs in the treatment of OA rats, which can be used for subsequent validation.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CCL20 (C-C Motif Chemokine Ligand 20) • IL17A (Interleukin 17A) • MIR192 (MicroRNA 192) • MIR23A (MicroRNA 23a) • NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) • AKAP12 (A-Kinase Anchoring Protein 12) • ARHGDIB (Rho GDP Dissociation Inhibitor Beta) • EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) • MIR146B (MicroRNA 146b) • MIR214 (MicroRNA 214) • MIR222 (MicroRNA 222) • MIR30E (MicroRNA 30e) • MIR342 (MicroRNA 342)
    1year
    Single-cell transcriptome analysis identifies subclusters and signature with N-glycosylation in endometrial cancer. (PubMed, Clin Transl Oncol)
    Our study underscores the role of N-glycosylation-related genes in EC prognosis and immunotherapy response prediction, and may provide a basis for the development of targeted therapies and personalized treatment strategies.
    Journal • IO biomarker
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    KRT7 (Keratin-7) • IL32 (Interleukin 32) • LAMC2 (Laminin subunit gamma 2) • AKAP12 (A-Kinase Anchoring Protein 12) • KRT18 (Keratin 18) • SERPINA1 (Serpin Family A Member 1) • SOX4 (SRY-Box Transcription Factor 4)
    over1year
    Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma. (PubMed, Sci Rep)
    It also exhibited lower tumor mutation burden, mRNAsi, and EREG-mRNAsi and reduced sensitivity to other chemotherapy drugs, except dasatinib. These findings serve as a valuable indicator for personalized treatment strategies and clinical stratification in managing patients with EOC. Additionally, our study will serve as a foundation for future mechanistic research to explore the association between the ubiquitin-proteasome pathway and EOC.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • CD4 (CD4 Molecule) • EREG (Epiregulin) • STAT1 (Signal Transducer And Activator Of Transcription 1) • VPS18 (VPS18 Core Subunit Of CORVET And HOPS Complexes) • AKAP12 (A-Kinase Anchoring Protein 12) • FBXO9 (F-Box Protein 9) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G)
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    TMB-L
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    dasatinib