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AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

News alerts, weekly reports and conference planners

Cross-Regional Transcriptome Data Reveal Transcriptional Abnormalities Associated with Lung Adenocarcinoma. (PubMed, Rep Biochem Mol Biol)

Our findings suggest that the expression levels of serglycin, ILK, ESD, and PLPD1 may play a significant role in the development of LAC. This information can be valuable for identifying potential treatment targets for lung cancer.

1 month ago

Journal

CD123 (Interleukin 3 Receptor Subunit Alpha) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • KRT19 (Keratin 19) • AQP1 (Aquaporin 1) • BST1 (Bone Marrow Stromal Cell Antigen 1) • COL3A1 (Collagen Type III Alpha 1 Chain) • SMAD7 (SMAD Family Member 7) • TAGLN (Transgelin) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • AKAP12 (A-Kinase Anchoring Protein 12) • RGS2 (Regulator Of G Protein Signaling 2) • NCOA1 (Nuclear Receptor Coactivator 1)

6ms

Response to anti-angiogenic therapy is associated with AIMP protein family expression in glioblastoma and lower-grade gliomas. (PubMed, Cancer Res Commun)

Single-cell analysis revealed homogeneous AIMP2 expression in tumor tissues, particularly in AC-like cells, suggesting a mechanistic link to tumor angiogenesis. These findings provide novel insights into the role of AIMPs in angiogenesis, offering improved patient stratification and therapeutic outcomes in recurrent GBM.

6 months ago

Journal

AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

9ms

Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes. (PubMed, J Physiol Biochem)

Furthermore, this study revealed evidence suggesting that QARS1 may influence breast cancer cell proliferation through methionine metabolism. This analysis provides valuable insights into the mechanisms of breast cancer, emphasizing the significance of AAMRGs as prognostic biomarkers and potential therapeutic targets for optimizing personalized treatment strategies.

9 months ago

Journal

AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

11ms

Response to anti-angiogenic therapy is affected by AIMP protein family activity in glioblastoma and lower-grade gliomas. (PubMed, bioRxiv)

11 months ago

Journal

AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

1year

The Dual Role of Survival Genes in Neurons and Cancer Cells: a Strategic Clinical Application of DX2 in Neurodegenerative Diseases and Cancer. (PubMed, Biomol Ther (Seoul))

It is noteworthy that genes that were previously classified as oncogenes, such as AKT and XBP1, are now being considered as curative transgenes for targeting neurodegenerative diseases. A strategic direction for clinical application of survival genes in neurogenerative disease and in cancer is justified.

1 year ago

Journal

KRAS (KRAS proto-oncogene GTPase) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • XBP1 (X-box-binding protein 1) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

over1year

The therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progression. (PubMed, Mol Ther Oncol)

Moreover, the elimination of DX2 using small interfering RNA (siRNA) or an optimized inhibitor (SNU-14) blocked the induction of HER2 and Shh and completely suppressed tumor sphere formation in response to nicotine. These results indicate that DX2 is critical for lung cancer progression, and a specific DX2 inhibitor would be useful for the treatment of human cancers, including SCLC and non-SCLC (NSCLC).

over 1 year ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

over1year

Chemical induction of the interaction between AIMP2-DX2 and Siah1 to enhance ubiquitination. (PubMed, Cell Chem Biol)

SDL01 was found to bind to the pocket surrounding the N-terminal flexible region and GST domain of DX2, causing a conformational change that stabilized its interaction with Siah1. Our findings demonstrate that protein-protein interactions (PPIs) can be modulated through chemically induced conformational changes.

over 1 year ago

Journal

AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

over1year

MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolism. (PubMed, Oncol Lett)

Co-immunoprecipitation experiments demonstrated that MTCH2 interacts with AIMP2 and claudin-3. The present study provides novel insights into the treatment of OC metastasis, as MTCH2 was demonstrated to serve roles in the progression of OC cells through the regulation of claudin-3 via AIMP2, which could provide novel insights into the treatment of ovarian cancer metastasis.

over 1 year ago

Journal

AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • CLDN3 (Claudin 3)

over1year

Identification and structure of AIMP2-DX2 for therapeutic perspectives. (PubMed, BMB Rep)

There is growing interest in AIMP2-DX2 as a promising biomarker for prognosis and diagnosis, with AIMP2-DX2 inhibition attracting significant interest as a potentially effective therapeutic approach for the treatment of lung, ovarian, prostate, and nasopharyngeal cancers. [BMB Reports 2024; 57(7): 318-323].

over 1 year ago

Clinical • Observational data • Retrospective data • Review • Journal

TNFA (Tumor Necrosis Factor-Alpha) • TGFB1 (Transforming Growth Factor Beta 1) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

2years

Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer. (PubMed, Curr Genomics)

Finally, siRNA-mediated AIMP2 knockdown inhibited BRCA cell proliferation and migration in vitro. In conclusion, our pan-cancer analysis suggests that AIMP2 may play a crucial role in tumor immunity and could serve as a potential prognostic marker, particularly in BRCA.

2 years ago

Journal • BRCA Biomarker • Pan tumor

BRCA (Breast cancer early onset) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

2years

Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson's disease treatment. (PubMed, J Transl Med)

Our CNS-specific vector system, which encodes a survival transgene DX2, signifies a promising avenue for safe gene therapy, avoiding unintended expression of survival gene in blood cells, applicable to various neurodegenerative diseases.

2 years ago

Journal

MIR142 (MicroRNA 142) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2)

2years

Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease. (PubMed, Acta Neuropathol Commun)

AIMP2 and DX2 are proposed to engage in bidirectional regulation of parthanatos. They physically interact with PARP-1. Notably, DX2's cell survival properties manifest exclusively in the context of abnormal AIMP2 accumulation, devoid of any tumorigenic effects. This suggests that DX2 could represent a distinctive therapeutic target for addressing Parkinson's disease in patients.

2 years ago

Journal

PARP1 (Poly(ADP-Ribose) Polymerase 1) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • SLC2A1 (Solute Carrier Family 2 Member 1)