^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    AIM2 deletion

    i
    Other names: AIM2, Absent In Melanoma 2, Interferon-Inducible Protein AIM2, PYHIN4
    Entrez ID:
    9447
    Related biomarkers:
    Expression
    1year
    Deletion of absent in melanoma-2 (AIM2) drives bone marrow adipogenesis and impairs bone microarchitecture. (PubMed, Geroscience)
    RNAseq analysis of the bone marrow revealed a significant increase in interferon-stimulated genes with Ifi202b as the top-upregulated gene in AIM2 null mice. Our findings suggest that AIM2 deficiency affects bone health by promoting adipogenesis in the bone marrow and inducing a pro-inflammatory environment, thereby contributing to decreased bone mineral density.
    Journal
    |
    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • IL18 (Interleukin 18) • AIM2 (Absent In Melanoma 2) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PDGFA (Platelet Derived Growth Factor Subunit A) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)
    |
    AIM2 deletion