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    DRUG:

    AGK2

    i
    Other names: AGK2
    Company:
    Chongqing Medical University, Harvard Medical School, Shanghai Jiao Tong University
    Drug class:
    SIRT2 inhibitor
    over2years
    Lactylation of METTL16 promotes cuproptosis via mA-modification on FDX1 mRNA in gastric cancer. (PubMed, Nat Commun)
    Combining elesclomol with AGK2, a SIRT2-specific inhibitor, induce cuproptosis in gastric tumors in vitro and in vivo. These results reveal the significance of non-histone protein METTL16 lactylation on cuproptosis in tumors. Given the high copper and lactate concentrations in GC, cuproptosis induction becomes a promising therapeutic strategy for GC.
    Journal
    |
    FDX1 (Ferredoxin 1) • METTL16 (Methyltransferase 16, RNA N6-Adenosine)
    |
    elesclomol (STA-4783) • AGK2