AFP (Alpha-fetoprotein)

Treatment involved a multimodal strategy combining transarterial chemoembolization (TACE), fractionated radiotherapy, and combination immunotherapy with camrelizumab plus apatinib. This case highlights the rare entity of direct renal invasion from HCC and provides practical insights into its diagnosis and comprehensive management. It illustrates the clinical feasibility and potential benefit of a combined locoregional and systemic strategy in advanced HCC with such uncommon extrahepatic renal involvement, underscoring the importance of individualized treatment in these complex presentations.

This model provided three risk strata for 2-year RFS, low risk, medium risk, and high risk, with 2-year RFS of 75%, 58%, and 35%, respectively (p < 0.001). We developed a risk prediction model to predict true early recurrence in patients undergoing RFA for early-stage HCC.

Calibration and decision curve analysis confirmed superior model performance and clinical net benefit. This nomogram quantifies the prognostic impact of adipose tissue distribution, providing an actionable preoperative tool to guide personalized TACE management-including alternative or intensified therapies for high-risk patients or standard care for low-risk individuals.

P2, N=46, Not yet recruiting, Fudan University

She previously received semaglutide and liraglutide (total 7 years) without hepatotoxicity...Early diagnosis and drug discontinuation resulted in resolution. If unrecognized, although rare, severe hepatic dysfunction with associated complications can result.

Current evidence suggests that AFP identifies biologically aggressive subsets of GEP-NENs, reflecting disease burden in specific contexts. While AFP should not be considered an independent biomarker, it holds potential as a contextual signal of aggressive tumor biology and as an adjunctive tool within integrated clinical and pathological frameworks.

Live imaging revealed no significant differences in cell membrane behavior and the morphology of the cancer cells between the sucrose-treated and untreated groups. On the whole, while the present study primarily focuses on phenotypic outcomes, the mechanisms underlying these observations remain to be elucidated in future studies.

This case report reviews the literature on histologically similar testicular tumors and summarizes diagnostic and management experiences. For testicular mixed germ cell tumors in early adolescence, immediate radical orchiectomy can achieve clinical cure, and long-term follow-up is crucial.

Overall, while risk-stratified HCC surveillance has several promising characteristics over current paradigms, prospective validation and implementation studies are needed before widespread adoption. Aligning surveillance strategies with individualized risk has the potential to improve outcomes in patients at risk for HCC.

Different etiologies, diets, medications, and complications can lead to significant confounding and affect cross cohort consistency. Subsequent research requires longitudinal cohort validation and the promotion of multi omics integration and the construction of interpretable predictive models to support clinical translation.

Our patient presented with a visceral crisis denoted by impending liver failure, prompting the urgent initiation of first-line systemic therapy with fluorouracil, leucovorin, oxaliplatin and trastuzumab. This resulted in rapid clinical improvement, normalisation of liver function tests and tumour markers, and radiographic response with approximately 50% reduction in hepatic metastatic disease burden. This case underscores the aggressive behaviour and rarity of HER2-positive, AFP-producing gastric cancer, highlighting the critical need for prompt diagnosis and initiation of systemic therapy.