^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    AFP expression

    i
    Other names: AFP, Alpha-fetoprotein, FETA, HPAFP
    Entrez ID:
    174
    Related biomarkers:
    Others
    6d
    AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane. (PubMed, Transl Oncol)
    AFP enhanced CD47 membrane translocation by interacting with HuR. These findings proved that AFP could inhibit macrophage to phagocytize HCC cells by upregulating the localization of CD47 on the HCC cell surface. Combination of AFP with CD47 blockade may be a potential therapeutic strategy for HCC treatment.
    Journal
    |
    CD47 (CD47 Molecule) • AFP (Alpha-fetoprotein)
    |
    CD47 overexpression • AFP expression
    16d
    STING Nanoagonist Boosts Antitumor Immunity of Therapeutic DNA Vaccines. (PubMed, Nano Lett)
    MSNA combined with a DNA plasmid encoding the human papillomavirus type 16 oncoproteins E6 and E7 induced potent E7-specific CD8 T cell responses, preventing the growth of E7-expressing solid TC-1 tumors and promoting the shrinkage of E7-expressing skin grafts. These findings together demonstrate that coadministration of MSNA can improve the efficacy of therapeutic DNA vaccines targeting cancer-specific antigens.
    Journal
    |
    CD8 (cluster of differentiation 8) • AFP (Alpha-fetoprotein) • STING (stimulator of interferon response cGAMP interactor 1)
    |
    AFP expression
    1m
    Nlrp6 overexpression inhibits lipid synthesis to suppress proliferation of hepatocellular carcinoma cells by regulating the AMPK-Srebp1c axis (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
    Nlrp6 overexpression inhibits lipid synthesis in HCC cells by regulating the AMPK-Srebp1c axis, which might be a key pathway for suppressing HCC cell proliferation.
    Journal
    |
    NLRP6 (NLR Family Pyrin Domain Containing 6) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
    |
    AFP expression • NLRP6 overexpression • AMPK expression
    8ms
    Alpha-fetoprotein: Past, present, and future. (PubMed, Hepatol Commun)
    In addition to its role as a biomarker, AFP plays important roles in immune modulation to promote tumorigenesis and thus has been investigated as a therapeutic target in HCC. In this review article, we aim to provide an overview of AFP, encompassing the discovery, biological role, and utility as an HCC biomarker in combination with other biomarkers and how it impacts clinical practice and future direction.
    Journal
    |
    AFP (Alpha-fetoprotein) • ALB (Albumin)
    |
    AFP expression
    9ms
    Ratiometric electrochemical immunoassay based on 2D Co/Fe MOF decorated with toluidine blue and Fc-labeled Schiff base for accurate assay of alpha-fetoprotein in clinical serum. (PubMed, Talanta)
    When applied to the assay of clinical serum samples, the detection results of ratiometric sensor were consistent with that of commercial electrochemiluminescence (ECL) immunoassay, significantly superior to that of non-ratiometric sensor. The self-calibrated strategy based on ratiometric sensor helps to improve the accuracy of AFP in clinical diagnosis.
    Journal
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    11ms
    Clinicopathological features of gastric alpha-fetoprotein-producing adenocarcinoma with SWI/SNF complex deletion (PubMed, Zhonghua Bing Li Xue Za Zhi)
    Postoperative adjuvant chemotherapy was given to three patients. AFP-producing adenocarcinoma is a rare subtype of gastric cancer, which can be combined with SWI/SNF complex deletion, and the pathomorphological manifestations are different from the classical SWI/SNF complex deletion of undifferentiated carcinoma with rhabdoid phenotype.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ARID1A (AT-rich interaction domain 1A) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • CDH1 (Cadherin 1) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein) • GPC3 (Glypican 3) • SALL4 (Spalt Like Transcription Factor 4) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2)
    |
    ARID1A deletion • SMARCA4 deletion • SMARCB1 deletion • CDH1 expression • GPC3 expression • AFP expression
    12ms
    Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma. (PubMed, Metabolism)
    STAT3-NFκβ signaling axis has a significant role in mitochondrial dysfunction and metabolic alterations in the development of HCC.
    Journal • PARP Biomarker
    |
    PTEN (Phosphatase and tensin homolog) • IL6 (Interleukin 6) • AFP (Alpha-fetoprotein) • CASP3 (Caspase 3)
    |
    AFP expression • PARP1 expression
    12ms
    Obesity phenotype induced by high-fat diet promotes diethylnitrosamine (DEN)-induced precancerous lesions by M1 macrophage polarization in mice liver. (PubMed, J Nutr Biochem)
    Additionally, angiogenesis was revealed by immunostaining assay to be associated with the inflammatory response. All the results demonstrate that obesity promotes DEN-induced precancerous lesions by inducing M1 macrophage polarization and angiogenesis.
    Preclinical • Journal
    |
    AFP (Alpha-fetoprotein) • GSTP1 (Glutathione S-transferase pi 1)
    |
    AFP expression
    12ms
    Lysosomes Initiating and DNAzyme-Assisted Intracellular Signal Amplification Strategy for Quantification of Alpha-Fetoprotein in a Single Cell. (PubMed, Anal Chem)
    Results demonstrated overexpression of alpha-fetoprotein in hepatocellular carcinoma cells. This strategy represents a novel technique for single-cell protein analysis and holds significant potential as a powerful tool for such analyses.
    Journal
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    1year
    Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma. (PubMed, Immunol Invest)
    In this study, we showed that vaccination with alpha-fetoprotein-expressing dendritic cells in combination with a specific inhibition of regulatory T-cells by using P60 leads to synergistic tumor inhibition and prolonged survival. This emphasizes the importance of regulatory T-cells inhibition for obtaining an effective antitumoral immune response in hepatocellular carcinoma.
    Journal
    |
    AFP (Alpha-fetoprotein) • FOXP3 (Forkhead Box P3)
    |
    AFP expression
    1year
    Kidney-type glutaminase is a biomarker for the diagnosis and prognosis of hepatocellular carcinoma: a prospective study. (PubMed, BMC Cancer)
    It was validated that GLS1 was a sensitive and specific biomarker for pathological diagnosis of HCC and had prognostic value, thus having practical value for clinical application.
    Journal
    |
    KDR (Kinase insert domain receptor) • AFP (Alpha-fetoprotein) • GPC3 (Glypican 3) • GLS1 (Glutaminase)
    |
    KDR expression • GPC3 expression • AFP expression
    1year
    Portal vein tumour thrombosis radiotherapy improves the treatment outcomes of immunotherapy plus bevacizumab in hepatocellular carcinoma: a multicentre real-world analysis with propensity score matching. (PubMed, Front Immunol)
    Multivariate Cox analysis showed that AFP expression, gross classification of HCC, PVTT type, extrahepatic metastasis, PVTT radiotherapy, and reduction in PVTT were independent factors influencing PFS (P < 0.05). Sequential ICIs plus bevacizumab therapy after radiotherapy for PVTT in patients with HCC is safe and feasible and may further prolong the PFS of patients.
    Retrospective data • Journal • Real-world evidence • IO biomarker • Real-world
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    AFP expression
    |
    Avastin (bevacizumab)
    1year
    Clinical Significance of Primary Tumour Size in Testicular Neoplasms (EMUC 2023)
    Conclusions The present study confirm TS is associated with CS, because maybe tumor growth induce intratumoral processes promoting metastatic spread. TS has potential value in predicting histology, but there are limited data to establish a size for a clinical threshold.
    Clinical
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    1year
    INTERFERON-RELATED GENE EXPRESSION CHANGES MEDIATED BY ALPHA-FETOPROTEIN IN PATIENTS WHO DEVELOPED HEPATOCELLULAR CARCINOMA AFTER HEPATITIS C VIRUS ERADICATION (AASLD 2023)
    These results showed a correlation between the elevated AFP gene expression in hepatocellular carcinoma tissue with elevated interferon-α-related gene expression and altered VEGFA gene expression in patients with chronic liver disease with slightly elevated serum AFP levels in the range of less than 20 ng/ml. These results suggest that even a slight increase in AFP expression may have a certain impact on the hepatocellular carcinoma microenvironment.
    Clinical
    |
    AFP (Alpha-fetoprotein)
    |
    AFP elevation • VEGFA elevation • VEGFA expression • AFP expression
    1year
    GPC3 gene expression and allelic discrimination of FZD7 gene in Egyptian patients with hepatocellular carcinoma. (PubMed, Rep Pract Oncol Radiother)
    FZD7 and GPC3 gene expressions have a complementary role in early HCC detection, with a greater diagnostic sensitivity and accuracy than AFP. In addition, FZD7 rs2280509 polymorphism is significantly associated with an increased risk of HCC in the Egyptian population.
    Journal
    |
    AFP (Alpha-fetoprotein) • GPC3 (Glypican 3) • FZD7 (Frizzled Class Receptor 7)
    |
    GPC3 expression • AFP expression
    1year
    An Insight Into the Role of Alpha-Fetoprotein (AFP) in the Development and Progression of Hepatocellular Carcinoma. (PubMed, Mol Biotechnol)
    The article also focuses on information about the structure, biosynthesis, and regulation of AFP at the gene level. Additionally, it discusses the immune evasion, metastasis, and control of gene expression that AFP mediates during HCC.
    Review • Journal
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    1year
    β-Sitosterol activates autophagy to inhibit the development of hepatocellular carcinoma by regulating the complement C5a receptor 1/alpha fetoprotein axis. (PubMed, Eur J Pharmacol)
    Our findings demonstrate that β-sitosterol inhibits HCC advancement by activating autophagy through the complement C5a receptor 1/AFP axis. These findings recommend β-sitosterol as a promising therapy for HCC.
    Journal
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    over1year
    Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis. (PubMed, Br J Cancer)
    Histological diagnosis of polyploidy using surrogate markers discriminates an aggressive subset of HCC, apart from known HCC subgroups, and predict poor prognosis in HCC.
    Journal
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    over1year
    Prognostic and pathological implications of contrast-enhanced ultrasound features in hepatocellular carcinoma. (PubMed, J Cancer Res Ther)
    The mosaic architecture and intratumoral feeding arteries of CEUS were closely related to the postoperative progression of HCC. Mosaic architecture had a good correlation with tumor size and MVI, whereas intratumoral feeding arteries were closely associated with tumor size and Ki-67 expression.
    Journal
    |
    AFP (Alpha-fetoprotein)
    |
    AFP expression
    over1year
    α-Fetoprotein contributes to the malignant biological properties of AFP-producing gastric cancer. (PubMed, Open Life Sci)
    The cell counting kit-8 cell proliferation assay, cell invasion, and migration assays confirmed that the AFP could affect the malignant biological behavior of AFP-GC. These findings suggest that AFP contributes to the malignant biological properties of AFP-GC and the high expression of c-Met in AFP-GC.
    Journal
    |
    MET (MET proto-oncogene, receptor tyrosine kinase) • AFP (Alpha-fetoprotein)
    |
    MET overexpression • MET expression • AFP expression