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    BIOMARKER:

    AFAP1-AS1 overexpression

    i
    Other names: AFAP1-AS1, AFAP1 Antisense RNA 1, AFAP1 Antisense RNA 1 (Non-Protein Coding), AFAP1 Antisense RNA (Non-Protein Coding)
    Entrez ID:
    84740
    3ms
    Actin filament-associated protein 1-antisense RNA1 promotes the development and invasion of tongue squamous cell carcinoma via the AFAP1-AS1/miR-133a-5p/ZIC2 axis. (PubMed, J Gene Med)
    The upregulation of lncRNA AFAP1-AS1, which increases TSCC cell viability, migration, proliferation and invasion via the AFAP1-AS1/miR-133a-5p/ZIC2 axis, aids in the progression of TSCC.
    Journal
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    AFAP1-AS1 (AFAP1 Antisense RNA 1) • ZIC2 (Zic Family Member 2)
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    AFAP1-AS1 overexpression
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    docetaxel • Tasigna (nilotinib) • fexagratinib (ABSK091) • AZD-7762
    10ms
    The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway. (PubMed, Oncol Res)
    Taken together, AFAP1-AS1 functions as an oncogene that activates the PLK1 signaling pathway. AFAP1-AS1 could be used as a potential prognostic marker and therapeutic target for TNBC.
    Journal
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    PLK1 (Polo Like Kinase 1) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • CDC25C (Cell Division Cycle 25C) • CDK1 (Cyclin-dependent kinase 1) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    |
    AFAP1-AS1 overexpression
    over1year
    LncRNA AFAP1-AS1 Induces Gefitinib Resistance of Lung Adenocarcinoma Through the miR-653-5p/AGR2 Axis. (PubMed, Ther Clin Risk Manag)
    Mechanically, AFAP1-AS1 sequestered the miR-653-5p and blocked the inhibition of miR-653-5p to AGR2 and stepwise upregulated AGR2 overexpression in LUAD gefitinib resistant cells, resulting gefitinib resistance in LUAD. AFAP1-AS1 promotes gefitinib-resistance LUAD cells through a previously unrecognized miR-653-5p/AGR2 axis, suggesting targeting AFAP1-AS1/miR-653-5p/AGR2 axis might be a promising way for LUAD intervention.
    Journal
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    AGR2 (Anterior gradient 2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • AFAP1 (Actin Filament Associated Protein 1)
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    AFAP1-AS1 overexpression • AGR2 overexpression • AGR2 expression
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    gefitinib
    almost2years
    Metformin suppresses lung adenocarcinoma by downregulating long non-coding RNA (lncRNA) AFAP1-AS1 and secreted phosphoprotein 1 (SPP1) while upregulating miR-3163. (PubMed, Bioengineered)
    Met exerts its antitumor activities by regulating the AFAP1-AS1/miR-3163/SPP1/PI3K/Akt/mTOR axis. Our findings deepen our understanding of mechanisms underlying anti-tumor effect of Met in LUAD.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • AFAP1 (Actin Filament Associated Protein 1) • MIR3163 (MicroRNA 3163)
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    AFAP1-AS1 overexpression
    |
    metformin
    2years
    AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1. (PubMed, Bioengineered)
    GNB1 silencing resulted in reduced proliferation and migration of RB cells and attenuated the oncogenic effect of the miR-545-3p inhibitor. Thus, in this study, a novel ceRNA regulation network of AFAP1-AS1 in RB was identified, where AFAP1-AS1 regulated GNB1 expression by targeting miR-545-3p, ultimately driving RB progression.
    Journal
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    CASP3 (Caspase 3) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • AFAP1 (Actin Filament Associated Protein 1)
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    AFAP1-AS1 overexpression
    over2years
    Silencing of LncRNA AFAP1-AS1 Inhibits Cell Proliferation in Oral Squamous Cancer by Suppressing CCNA2. (PubMed, Cancer Manag Res)
    Further research indicated that AFAP1-AS1 regulated OSCC cell proliferation by targeting CCNA2. AFAP1-AS1 promotes tumor proliferation and indicates a poor prognosis in OSCC, providing a potential therapeutic strategy.
    Journal
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    CCNA2 (Cyclin A2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • AFAP1 (Actin Filament Associated Protein 1)
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    AFAP1-AS1 overexpression
    over2years
    Long non-coding RNA AFAP1-AS1 promotes thyroid cancer progression by sponging miR-204-3p and upregulating DUSP4. (PubMed, J Biochem)
    AFAP1-AS1 augmented the expression of DUSP4 via repressing miR-204-3p, and the effects of AFAP1-AS1 overexpression on thyroid cancer cells were also partly abolished by miR-204-3p restoration. In summary, AFAP1-AS1 facilitates thyroid cancer cell proliferation, migration, and invasion by regulating miR-204-3p/DUSP4 axis.
    Journal
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    AFAP1-AS1 (AFAP1 Antisense RNA 1) • AFAP1 (Actin Filament Associated Protein 1)
    |
    AFAP1-AS1 overexpression
    almost3years
    LncRNA AFAP1-AS1 Modulates the Proliferation and Invasion of Gastric Cancer Cells by Regulating AFAP1 via miR-205-5p. (PubMed, Cancer Manag Res)
    Moreover, miR-205-5p has been well demonstrated to participate in the regulation of AFAP1 expression and the phenotypes of GC cells, including proliferation, migration and invasion. AFAP1-AS1, as a novel biomarker of GC, promotes the proliferation migration and invasion of GC cells and function as ceRNA to target AFAP1 by sponging miR-205-5p.
    Journal
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    AFAP1-AS1 (AFAP1 Antisense RNA 1) • AFAP1 (Actin Filament Associated Protein 1) • MIR205 (MicroRNA 205)
    |
    AFAP1-AS1 overexpression