ADRB2 (Adrenoceptor Beta 2)

MTN is a promising therapeutic agent for NSCLC by suppressing the migration via ADRB2 and EMT mechanisms. Please cite this article as: Iksen I, Singharajkomron N, Wongtayan A, Wattanathamsan O, Choonhapan A, Wademonkolgorn S, Nguyen HM, Hoang THX, Nguyen HT, Pongrakhananon V. Unveiling the antimetastatic activity and molecular mechanism of montanine in lung cancer cells via the integration of network pharmacology approaches with in vitro and in vivo investigations. J Integr Med. 2026; Epub ahead of print.

Reduced sympathetic tone elevates epithelial-derived signals to promote CD8+ TRM development in the skin epithelium, while heightened sympathetic activity during acute stress dampens this process. Our findings unveil a neuro-epithelial-immune tri-lineage axis that calibrates local CD8+ TRM abundance in the skin, enabling rapid adjustment of immunosurveillance strength at the barrier interface by inputs from the sympathetic nervous system.

Importantly, ADRB2/QPRT overexpression in hepatocytes, or nicotinamide administration, recovers CD8+ T cell function in stressed mice and reduces liver cancer progression. These findings identify a stress-responsive metabolic checkpoint in the liver that links the nervous system to immune surveillance and may be therapeutically targeted in liver cancers.

Our findings unveil a brain-cartilage circuit that regulates cartilage regeneration, providing valuable insights into the inherent limitations of tissue regeneration and suggesting a promising treatment strategy for enhancing cartilage regeneration.

These cells were then exposed to norepinephrine (NE), epinephrine (EPI), or corticosterone (CC)...Moreover, tumors from mice subjected to restraint stress had elevated expression of Notch1, Jagged 2, NICD, HES1, GR, ADRB2, and pS9-GSK3β. These data indicate that chronic stress leads to MDSCs infiltration and suppressive activity, which contributes to an immunosuppressive TME and OC progression.

This article discusses the probable mechanism of action of semen strychni in the treatment of glioma, which can serve as a theoretical basis and evidence for subsequent experimental investigations.

Gymconopin C exerts tumor-suppressive effects by activating PINK1/Parkin-mediated mitophagy via the miR-6777-5p/ADRB2 axis, highlighting its potential as a therapeutic agent for NSCLC.

A gene-based analysis of rare, nonsynonymous ADRB2 variants, identified a novel association with nonrheumatic pulmonary valve disorders, but no association with lung function. In conclusion, the lung function-lowering allele of Thr164Ile is associated with traits and proteins indicative of a role in immune and lipid metabolism pathways, suggesting potential targets for therapeutic intervention.

Clinical and cohort studies consistently associate elevated stress markers with increased metastasis risk, and interventions-ranging from β-blockers and GR antagonists to cognitive-behavioral therapy-show promise in mitigating these effects. Future advances in multi-omics, spatial profiling, smart probiotics, and optogenetic tools are poised to unravel the complex "stress-tumor" interface and enable precise, integrative mind-body therapeutic strategies.

Docking studies showed that the nsBB with the highest binding affinity (ΔG) was carvedilol (-10.5 kcal/mol), followed by propranolol (-8.5 kcal/mol). Notably, differences in receptor affinity were observed among the nsBBs, with carvedilol exhibiting the strongest binding affinity values on ADRB2, ERBB2, and NPYR as biological targets against BC cells. These promising results require future experimental validation.

These effects were partially reversed by propranolol, a non-selective beta-adrenergic receptor antagonist...This diversity underscores the complexity of adrenergic signaling in breast cancer and highlights the advantages of 3D culture systems. These results provide valuable insights into the subtype-specific patterns of response to adrenergic signaling that contribute to tumor progression and may inform future studies including evaluation of therapeutic strategies.

This study highlights GMCRRDEGs as AMI biomarkers, emphasizing their role in disease mechanisms and immune responses. Further research should validate these findings in larger cohorts to enhance early detection for AMI.