However, T-cells are incapable of producing their own IL-7 and rely on secretion from surrounding stromal cells.11 We hypothesize that the introduction of an inducible IL-7 gene to TILs (next generation TIL; ADP-TILIL7) will improve their ability to engraft, proliferate, and survive, while maintaining diverse TIL specificity...Nat Rev Immunol. 2011;11(5):330.
over 2 years ago
Clinical • Tumor-Infiltrating Lymphocyte
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MAGEA4 (Melanoma antigen family A, 4) • IL7 (Interleukin 7) • NFATC1 (Nuclear Factor Of Activated T Cells 1)