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    GENE:

    ADNP (Activity Dependent Neuroprotector Homeobox)

    i
    Other names: ADNP, Activity Dependent Neuroprotector Homeobox, ADNP1, Activity-Dependent Neuroprotective Protein, KIAA0784, Activity-Dependent Neuroprotector Homeobox Protein, Activity-Dependent Neuroprotector, ADNP Homeobox 1, HVDAS, MRD28
    Associations

    News

    Trials
    10ms
    ADNP Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing ADNP-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures. (clinicaltrials.gov)
    P=N/A, N=30, Recruiting, Icahn School of Medicine at Mount Sinai | Trial completion date: Mar 2026 --> Mar 2027 | Trial primary completion date: Mar 2026 --> Mar 2027
    Trial completion date • Trial primary completion date
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    ADNP (Activity Dependent Neuroprotector Homeobox)
    over1year
    Potential utility of ADNP in circulating tumor cells as biomarker for prognostics in non-muscle-invasive bladder cancer. (PubMed, Sci Rep)
    The preoperative ADNP mRNA level in CTCs was identified as a prognostic indicator for NMIBC. Longitudinal monitoring of ADNP mRNA in CTCs of bladder cancer patients shows promise in evaluating treatment responses and predicting prognosis.
    Journal • Circulating tumor cells • Tumor cell
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    ADNP (Activity Dependent Neuroprotector Homeobox)
    almost2years
    ADNP Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing ADNP-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures. (clinicaltrials.gov)
    P=N/A, N=30, Recruiting, Icahn School of Medicine at Mount Sinai | Trial completion date: Apr 2025 --> Mar 2026 | Trial primary completion date: Apr 2025 --> Mar 2026
    Trial completion date • Trial primary completion date
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    ADNP (Activity Dependent Neuroprotector Homeobox)
    over2years
    NAP (Davunetide): The Neuroprotective ADNP Drug Candidate Penetrates Cell Nuclei Explaining Pleiotropic Mechanisms. (PubMed, Cells)
    Ketamine, used as a control, was ineffective, but both NAP and ketamine exhibited direct interactions with ADNP, as observed via in silico docking. (4) Through a microtubule-linked mechanism, NAP rapidly localized to the cytoplasmic and nuclear compartments, ameliorating mutated ADNP-related deficiencies. These novel findings explain previously published gene expression results and broaden NAP (davunetide) utilization in research and clinical development.
    Journal
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    ADNP (Activity Dependent Neuroprotector Homeobox)