ADIPOQ (Adiponectin)

FABP4 is a promising independent prognostic biomarker for EOCRC, associated with an immunosuppressive microenvironment and maybe a potential guidance for immunotherapy and chemotherapy selection. Further multi-center prospective studies are warranted to validate its clinical utility.

RPL29 downregulation following 2 Gy radiotherapy correlates with improved prognosis in MM, highlighting its potential as a clinically relevant prognostic biomarker. These findings provide new insights into MM biology and establish a foundation for targeted therapeutic strategies involving RPL29 and related pathways.

The results of expressional analysis show that CDKN2B is significantly overexpressed in cardiovascular patients, while the gene ADIPOQ showed significant downregulation. The findings show that the CDKN2B and ADIPOQ gene polymorphisms significantly raise the risk for CVD, while their expression shows a significant correlation with CVD.

The integration of Omics data through WGCNA uncovered key interconnected gene modules, emphasizing the critical role of lipid metabolism in cancer progression. These results underscore the need for targeted therapeutic strategies to restore hub gene expression and to present potential biomarkers for early diagnosis and treatment. Moreover, lipid metabolism emerged as a pivotal pathway in breast cancer progression, suggesting that its regulation could be essential not only for targeted therapies but also for the prevention and control of the disease. This approach offers promising avenues for early intervention that could potentially reduce cancer risk.

In tissue with higher expression of IL6 and ADIPOQ, a higher abundance of M2-like macrophage gene expression was identified. This study revealed perioperative systemic dynamics of inflammatory mediators and identified local immune-adipose-metabolism gene expression in tumour-adjacent tissue associated with pro-tumour function.

We could further show that adipose Kiss1 deficiency leads to reduced peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) protein content of soleus muscle and maximum oxygen uptake (VO2 max) of female mice after prolonged exercise. Therefore, adipose Kisspeptin may be a novel adipokine that increases organ sensitivity to glucose, lipids, and oxygen following exercise.

Both compounds seem to affect adipocyte aromatase expression in vitro, where ethanol increased aromatase expression PPARγ-dependently and ethylene glycol decreased aromatase expression independently of PPARγ. No acute effects on aromatase expression or PPARγ activity were observed in adipose tissue or ovary in rats in this study design.

Notably, the specific downstream pathways involved varied depending on the type of tumors. These insightful findings not only confirm the consistent inhibitory effects of BPNSs across different tumor cells, but also elucidate the cytotoxicity mechanisms of BPNSs in different tumors, providing valuable information for their safe application and health risk assessment.

This study constructed and analyzed a circRNA-associated ceRNA regulatory network and uncovered that hsa_circ_0000375 exerted its anti-oncogene effect via sponge of miR-7706.

Finally, we constructed an lncRNA/miRNA/mRNA ceRNA network consisted of 2 lncRNAs, 15 mRNAs, and 4 miRNAs. This network represents an appropriate target for design of anti-cancer modalities and documentation of novel markers for breast cancer.

In addition, a significant association was observed between the TT genotype (mutant) of the ADIPOQ rs1501299 polymorphism and iron overload. These results demonstrate the importance of a comprehensive and systematic evaluation in patients with MDS, in order to identify and control negative factors not related to the disease at an early stage.

In addition, survival analysis demonstrated a statistically significant relationship between ADIPOQ, SLC7A5, and overall survival rates in CRC patients. In conclusion, our findings suggest that downregulation of ADIPOQ and upregulation of SLC7A5 in tumor cells lead to increased mTORC1 activity, reduced autophagy, enhanced angiogenesis, and ultimately contribute to cancer progression and decreased survival in CRC patients.