^
Contact us  to learn more about
our Premium Content:  News alerts, weekly reports and conference planners
GENE:

ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)

i
Other names: ADHFE1, Alcohol Dehydrogenase Iron Containing 1, Hydroxyacid-Oxoacid Transhydrogenase, Mitochondrial, Alcohol Dehydrogenase Iron-Containing Protein 1, HOT, Fe-Containing Alcohol Dehydrogenase 1, Hydroxyacid-Oxoacid Transhydrogenase, Fe-Containing Alcohol Dehydrogenase, Alcohol Dehydrogenase 8, HMFT2263, FLJ32430, ADHFE1, ADHFe1, ADH8
Associations
Trials
2ms
Diagnostic Accuracy of Multitarget Stool DNA Test for Colorectal Cancer Screening and Detecting in Thailand. (PubMed, Asian Pac J Cancer Prev)
Multitarget stool DNA testing is highly sensitive and specific for CRC detection in Thai individuals. This testing could represent as a viable non-invasive alternative to colonoscopy especially in settings where colonoscopy is less accessible or less accepted by patients.
Journal
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) • SDC2 (Syndecan 2)
over1year
Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening. (PubMed, J Cancer Res Clin Oncol)
The results of this study verified that the methylation levels of SDC2, ADHFE1 and PPP2R5C in stool DNA were significantly increased in CRC patients. Combined detection of SDC2/ADHFE1/PPP2R5C methylation is a potential non-invasive diagnostic method for CRC and precancerous lesion screening.
Journal
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) • SDC2 (Syndecan 2)
over1year
A large-scale real-world study for colorectal cancer screening (ESMO 2023)
Compared to a national CRC program implemented in Hubei Province between 2018 and 2019 using fecal immunochemical tests and CRC risk assessment questionnaires, current program showed a lower initial positive rate (4.4% vs. 17.4%), higher PPVs for CRC (1.3% vs. 0.08%) in the age-matched group, and a higher adherence rate for colonoscopy (71.3% vs. 18.2%). Conclusions Preliminary prospective evidence suggested that fecal DNA tests had promising diagnostic yield in population-based CRC screening, outperforming FIT/risk assessment questionnaire-based screening strategy.
Real-world evidence • Clinical • Real-world
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) • SDC2 (Syndecan 2)
|
COLOTECT™ 1.0
almost2years
Identifying DNA methylation biomarkers in Brazilian women of African descent (AACR 2023)
We are currently analyzing the associations between the top differentially methylated regions with ancestry informative markers, and the clinicopathological characteristics of disease, to gain a better understanding of the role of DNA methylation marks in this population. This study adds to our current knowledge on epigenetics marks that will ultimately help us address mortality due to this disease in this population.
Clinical • Epigenetic controller
|
ER (Estrogen receptor) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) • TFF1 (Trefoil Factor 1) • ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • CERK (Ceramide Kinase)
|
ER negative
almost2years
DNA methylation-based patterns for early diagnostic prediction and prognostic evaluation in colorectal cancer patients with high tumor mutation burden. (PubMed, Front Oncol)
CRC patients with low-risk scores combined with TMB levels represent a favorable survival. By integrating analyses of methylation and mutation data, it is suggested that DNA methylation patterns combined with TMB serve as a novel potential biomarker for early screening in more high-TMB populations and for evaluating the prognostic effect of CRC patients with ICI therapy.
Journal • Tumor mutational burden • IO biomarker • Epigenetic controller
|
TMB (Tumor Mutational Burden) • MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) • ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)
|
TMB-H
2years
Upregulated ENC1 predicts unfavorable prognosis and correlates with immune infiltration in endometrial cancer. (PubMed, Front Cell Dev Biol)
Then we looked into it further and discovered that ENC1 expression was linked to tumor microenvironment and predicted various immunological checkpoints. In conclusion, our data indicate that ENC1 may be required for the development of UCEC and may serve as a future biomarker for diagnosis and therapy.
Journal
|
NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) • PER3 (Period Circadian Regulator 3) • ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • ATF3 (Activating Transcription Factor 3) • PKM (Pyruvate Kinase M1/2) • THRA (Thyroid Hormone Receptor Alpha)
2years
Genome-wide DNA methylation profiling of gastric cardia cancer. (PubMed, J Gastroenterol Hepatol)
Our results reveal DNA methylation aberrations in GCC and that ADHFE1 gene DNA methylation contributes to the risk of GCC, thus providing novel mechanistic insights into gastric cardia cancer carcinogenesis.
Journal • Epigenetic controller
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)
2years
Four methylation-driven genes detected by linear discriminant analysis model from early-stage colorectal cancer and their methylation levels in cell-free DNA. (PubMed, Front Oncol)
Furthermore, the methylation levels of iRFE MDGs were correlated with the genes involved in the reprogramming process of somatic cells to pluripotent stem cells, which is considered the common signature of cancer cells and embryonic stem cells. The above results indicated that the four iRFE MDGs may play roles in the early stage of colorectal carcinogenesis and highlighted the complicated relationship between tissue DNA and cell-free DNA (cfDNA).
Journal • Epigenetic controller
|
MAFB (MAF BZIP Transcription Factor B) • ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)
over2years
Transcriptional progressive patterns from mild to severe renal ischemia/reperfusion-induced kidney injury in mice. (PubMed, Front Genet)
This study illustrates the core molecular progressive patterns from mild to severe I/R kidney injury, laying the foundation for precautionary biomarkers and molecular intervention targets for exploration. In addition, the safe renal artery blocking time of nephron-sparing surgery that we currently accept may not be safe anymore.
Preclinical • Journal
|
PCNA (Proliferating cell nuclear antigen) • ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)
almost3years
Epigenome-Wide DNA Methylation Profiling in Colorectal Cancer and Normal Adjacent Colon Using Infinium Human Methylation 450K. (PubMed, Diagnostics (Basel))
In conclusion, aberrant DNA methylation is significantly involved in CRC pathogenesis and is associated with gene silencing. This study reports several potential important methylated genes in CRC and, therefore, merit further validation as novel candidate biomarker genes in CRC.
Journal • Epigenetic controller
|
TRIM3 (Tripartite Motif Containing 3) • ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • HOXB2 (Homeobox B2)
3years
Identification of early diagnostic biomarkers via WGCNA in gastric cancer. (PubMed, Biomed Pharmacother)
The expression levels of ITGAX, CCL14, ADHFE1, and HOXB13 in GC tumor tissues are considerably greater than in adjacent normal tissues. Systems biology approaches identified that these genes could be possible GC marker genes, providing ideas for other experimental studies in the future.
Journal
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • HOXB13 (Homeobox B13)
|
HOXB13 expression
3years
Alternative Splicing-Based Differences Between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Genes, Immune Microenvironment, and Survival Prognosis. (PubMed, Front Oncol)
Finally, we found two most significant splicing factors and further showed their protein crystal structure. The joint analysis of the AS events in HCC and ICC revealed novel insights into immune features and clinical prognosis, which might provide positive implications in HCC and ICC treatment.
Journal
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)
3years
Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test. (PubMed, Genes (Basel))
The sensitivity and specificity of integrating methylated ADHFE1, SDC2, and PPP2R5C for CRC detection achieved 84.6% and 92.3%, respectively. Through an integrated approach using genome-wide DNA methylation profiles and electronic medical records, we could design a biomarker panel that allows for early and accurate noninvasive detection of CRC using stool samples.
Journal • Epigenetic controller
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1) • PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) • SDC2 (Syndecan 2)
over3years
ADHFE1 is a correlative factor of patient survival in cancer. (PubMed, Open Life Sci)
Pathway analysis revealed its potential role in cancer-related biological processes, including energy metabolism, DNA replication, and cell cycle regulation. AHDFE1 mRNA expression and DNA methylation can potentially be used as diagnostic markers in cancer and might be of great value in predicting the survival of patients with cancer.
Clinical • Journal
|
ADHFE1 (Alcohol Dehydrogenase Iron Containing 1)