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GENE:

ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

News alerts, weekly reports and conference planners

Ethnic genomic diversity in esophageal squamous cell carcinoma. (PubMed, World J Gastrointest Oncol)

By integrating multi-ethnic multi-omics data, we highlight emerging biomarkers and therapeutic targets that may inform ancestry-aware screening, risk stratification, and individualized treatment strategies. Bridging these ethnic and molecular divides is essential for translating genomic discoveries into equitable precision oncology for ESCC.

8 days ago

Review • Journal

ALDH2 (Aldehyde Dehydrogenase 2 Family Member) • APOB (Apolipoprotein B) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

11d

Genetic risk stratification and preventive strategies for double primary HNSCC and ESCC: a single-center cohort study. (PubMed, Esophagus)

Heavy smoking was associated with the development of LVLs and poor prognosis in those with double primary cancers. ALDH2 and CYP2A6 may contribute to cancer risk, underscoring the importance of abstinence from alcohol and smoking in preventive healthcare.

11 days ago

Journal

ALDH2 (Aldehyde Dehydrogenase 2 Family Member) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

19d

Novel insights into the mechanism of formaldehyde-induced lung cancer: a network toxicology and molecular docking approach. (PubMed, Toxicol Mech Methods)

Single-cell RNA sequencing distribution analysis showed that ADH5 and ADH1B were significantly enriched in Fibroblasts cell clusters, and ADH7 was significantly enriched in Basal cells cell clusters. Our study provides key targets and pathways for understanding the complex molecular mechanisms by which FA affects lung cancer, reveals complex relationships that are difficult to find by traditional toxicological methods, and provides insights into strategies for preventing lung cancer caused by FA exposure.

19 days ago

Journal

ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide)

27d

SIAH2-WNK1 Signaling Drives Glycolytic Metabolism and Therapeutic Resistance in Colorectal Cancer. (PubMed, Int J Mol Sci)

CAF exposure enhanced SIAH2 expression, CSC spheroid growth, and resistance to fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy, whereas SIAH2 depletion effectively abrogated these effects. Collectively, these findings identify the SIAH2/WNK1 axis as a central metabolic regulator linking glycolysis, CSC maintenance, and microenvironment-driven therapy resistance in CRC, highlighting its potential as a therapeutic target.

27 days ago

Journal

LDHA (Lactate dehydrogenase A) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • WNK1 (WNK Lysine Deficient Protein Kinase 1) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • PFKP (Phosphofructokinase, Platelet)

5-fluorouracil • oxaliplatin • leucovorin calcium

Cross-Regional Transcriptome Data Reveal Transcriptional Abnormalities Associated with Lung Adenocarcinoma. (PubMed, Rep Biochem Mol Biol)

Our findings suggest that the expression levels of serglycin, ILK, ESD, and PLPD1 may play a significant role in the development of LAC. This information can be valuable for identifying potential treatment targets for lung cancer.

1 month ago

Journal

CD123 (Interleukin 3 Receptor Subunit Alpha) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • KRT19 (Keratin 19) • AQP1 (Aquaporin 1) • BST1 (Bone Marrow Stromal Cell Antigen 1) • COL3A1 (Collagen Type III Alpha 1 Chain) • SMAD7 (SMAD Family Member 7) • TAGLN (Transgelin) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • AKAP12 (A-Kinase Anchoring Protein 12) • RGS2 (Regulator Of G Protein Signaling 2) • NCOA1 (Nuclear Receptor Coactivator 1)

2ms

Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data. (PubMed, BMC Med)

We observed moderate-to-weak evidence supporting causal effects of alcohol consumption on risk of head/neck, oesophageal, and colorectal cancer, inconsistent evidence for liver cancer, and no evidence for breast cancer. Overall, human genetic data do not provide evidence that alcohol consumption is a cause of all cancers and suggest there may even be inverse associations with certain cancer types.

2 months ago

Journal

ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

2ms

Evaluation of Nanoparticle-Based Plasma Enrichment on Individuals with Primary and Metastatic Pancreatic Cancer. (PubMed, Cancers (Basel))

The significant increase in proteome depth allows a strong foundation for future large-scale experimental and comparative analysis. Lastly, similar conclusions could be reached from comparing different mass spectrometers (Orbitrap Astral and Orbitrap Ascend) and columns (depth and throughput) setups on the same dataset, although the depth approach on the newer Orbitrap Astral instrumentations can reveal additional insights in the plasma proteome.

2 months ago

Journal

ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

3ms

EMP1 + hepatic stellate cells drive hepatic fibrosis progression to hepatocellular carcinoma and predict prognosis. (PubMed, J Transl Med)

This study, through the integration of multi-omics data, establishes EMP1 as a reliable marker of activated HSCs. The genes NPY1R, CTHRC1, IGFBP3, and ADH1B play critical regulatory roles and exhibit prognostic value in the progression from hepatic fibrosis to HCC. Our findings provide novel insights and therapeutic targets for the use of Salvia miltiorrhiza in treating hepatic fibrosis and HCC.

3 months ago

Journal

NPY1R (Neuropeptide Y Receptor Y1) • IGFBP3 (Insulin-like growth factor binding protein 3) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

5ms

Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites. (PubMed, Nat Commun)

Subsite-specific analysis of the HLA region reveals distinct immune-related associations across HPV-positive and HPV-negative tumours. These findings refine the genetic architecture of HNSCC and highlight mechanisms linking inherited variation, immunity, and environmental exposures.

5 months ago

Journal

TP53 (Tumor protein P53) • BRCA2 (Breast cancer 2, early onset) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)

5ms

Development of a prognostic risk model for colorectal cancer based on microsatellite stability-associated genes. (PubMed, BMC Cancer)

Our analysis of microsatellite stability-associated genes in CRC highlights their impact on TIME, clinicopathological features, and prognosis, providing new insights into predicting prognosis and developing personalized treatments.

5 months ago

Journal • MSi-H Biomarker

MSI (Microsatellite instability) • CD36 (thrombospondin receptor) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • AQP8 (Aquaporin 8) • FABP4 (Fatty Acid Binding Protein 4)

MSI-H/dMMR

bleomycin

5ms

Construction of a novel prognostic model for gastric cancer based on pharmacokinetics-related genes and comprehensive prognostic analysis. (PubMed, Front Genet)

We have developed and validated an innovative prognostic risk model for GC, revealing that elevated ADMERGs risk scores are indicative of unfavorable prognosis and diminished immunotherapy response. These findings furnish molecular evidence regarding the participation of ADMERGs in modulating the immune microenvironment and therapeutic responsiveness in GC.

5 months ago

PK/PD data • Journal • IO biomarker

UGT1A1 (UDP glucuronosyltransferase family 1 member A1) • CD4 (CD4 Molecule) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide)

5ms

An integrative bioinformatic and Mendelian randomization study exploring the role of polyunsaturated fatty acid metabolism in laryngeal cancer. (PubMed, Discov Oncol)

Our findings suggest a potential mechanistic link between PUFA metabolism and LC susceptibility, generating hypotheses that PUFA-associated pathways may modulate immune microenvironment characteristics. This computational study provides preliminary insights into potential immunometabolic therapeutic strategies in laryngeal cancer that warrant experimental validation.

5 months ago

Journal

ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • ALDH7A1 (Aldehyde Dehydrogenase 7 Family Member A1)