Adenoid Cystic Carcinoma

In conclusion, NUF2 is upregulated in ACC and is associated with immune cell infiltration. Functional studies demonstrated that NUF2 promotes ACC cell proliferation and migration, suggesting its potential as a therapeutic target for ACC.

P=N/A, N=5, Not yet recruiting, Beijing Hospital; Beijing Hospital

P2, N=40, Recruiting, Eye, Ear, Nose & Throat Hospital of Fudan University; Eye, Ear, Nose & Throat Hospital of Fudan University

Although HER2-positive (3 +) was seen only in SDC, HER2-low and HER2-ultra-low expressions were not uncommon across salivary gland carcinomas, including SDCs and various non-SDC types. These findings suggest the potential applicability of HER2-targeted therapy in salivary gland carcinomas.

This review integrates the histopathological, molecular, and emerging spatial transcriptomic insights across this spectrum of rare and treatment-resistant prostate cancer subtypes. By highlighting shared mechanisms such as genomic instability, androgen receptor (AR) pathway bypass, and microenvironmental remodeling, we outline key diagnostic considerations and evolving therapeutic implications relevant to precision oncology.

The impact of immunohistochemical or molecular markers on treatment selection and response was most pronounced in SDC. HER2 IHC2 + expression was observed across multiple subtypes, indicating that TDxd may represent a potential treatment option for more pts than previously anticipated. The impact of comprehensive genomic profiling on targeted treatment options is currently still modest.

P1, N=30, Recruiting, Brigham and Women's Hospital | Trial completion date: Nov 2031 --> Aug 2029 | Trial primary completion date: Mar 2031 --> Apr 2029

Cancer surgery, radiotherapy, parotidectomy, neck dissection, chemotherapy, and cisplatin were the keywords of treatment...There have always been the common keywords such as pathology, tumor marker, immunohistochemistry, Ki-67, CRTC1, MAML2, gene fusion, and fluorescence in situ hybridization (FISH). This study for the first time elucidated the current scenario and scientometric characteristics of MEC, and would help in improving in reciprocal collaboration and provide helpful guidance for further research.

Combined use of LEF1 and β-catenin improved sensitivity (90%) but resulted in a medium specificity (93%). In conclusion, the proposed immunohistochemical panel can improve diagnostic accuracy in basaloid tumors of the salivary glands.

P2, N=1, Terminated, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | N=10 --> 1 | Trial completion date: Feb 2035 --> Jan 2026 | Recruiting --> Terminated | Trial primary completion date: Mar 2030 --> Nov 2025; Sponsor is no longer producing the study drug, so it was not possible to complete the study.

Recognition of recurrent diagnostic pitfalls, combined with a systematic pattern-based approach and judicious use of ancillary studies, is essential for accurate classification. Integration of morphologic, immunophenotypic, and molecular findings helps avoid misdiagnosis and ensures appropriate patient management.

P2, N=100, Recruiting, Eye & ENT Hospital of Fudan University | Not yet recruiting --> Recruiting