Adenoid Cystic Carcinoma

In conclusion, among the investigated biomarkers, only an analogous HLA class I expression in tumour tissue relative to that in the stromal tissue was associated with a reduced risk of recurrence in AdCC. These findings suggest a potential role of HLA class I as a prognostic marker in this rare malignancy.

P=N/A, N=600, Recruiting, Ohio State University Comprehensive Cancer Center | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026

The patient required no additional therapy and remains under close follow-up. This case highlights an exceptionally rare presentation of pulmonary myoepithelioma with bilateral pleural involvement - a pattern that can closely mimic metastatic disease - emphasizing the importance of histopathological and immunohistochemical assessment in differentiating benign myoepithelial tumors from metastatic or aggressive pleural lesions.

Accordingly, the article has been retracted as the editors no longer consider the article's conclusions to be reliable. The authors disagree with the retraction decision.

In conclusion, NUF2 is upregulated in ACC and is associated with immune cell infiltration. Functional studies demonstrated that NUF2 promotes ACC cell proliferation and migration, suggesting its potential as a therapeutic target for ACC.

P=N/A, N=5, Not yet recruiting, Beijing Hospital; Beijing Hospital

P2, N=40, Recruiting, Eye, Ear, Nose & Throat Hospital of Fudan University; Eye, Ear, Nose & Throat Hospital of Fudan University

Although HER2-positive (3 +) was seen only in SDC, HER2-low and HER2-ultra-low expressions were not uncommon across salivary gland carcinomas, including SDCs and various non-SDC types. These findings suggest the potential applicability of HER2-targeted therapy in salivary gland carcinomas.

This review integrates the histopathological, molecular, and emerging spatial transcriptomic insights across this spectrum of rare and treatment-resistant prostate cancer subtypes. By highlighting shared mechanisms such as genomic instability, androgen receptor (AR) pathway bypass, and microenvironmental remodeling, we outline key diagnostic considerations and evolving therapeutic implications relevant to precision oncology.

The impact of immunohistochemical or molecular markers on treatment selection and response was most pronounced in SDC. HER2 IHC2 + expression was observed across multiple subtypes, indicating that TDxd may represent a potential treatment option for more pts than previously anticipated. The impact of comprehensive genomic profiling on targeted treatment options is currently still modest.

P1, N=30, Recruiting, Brigham and Women's Hospital | Trial completion date: Nov 2031 --> Aug 2029 | Trial primary completion date: Mar 2031 --> Apr 2029

Cancer surgery, radiotherapy, parotidectomy, neck dissection, chemotherapy, and cisplatin were the keywords of treatment...There have always been the common keywords such as pathology, tumor marker, immunohistochemistry, Ki-67, CRTC1, MAML2, gene fusion, and fluorescence in situ hybridization (FISH). This study for the first time elucidated the current scenario and scientometric characteristics of MEC, and would help in improving in reciprocal collaboration and provide helpful guidance for further research.